Gastroprotective and antisecretory effects of <Emphasis Type="Italic">Ailanthus excelsa</Emphasis> (Roxb) |
| |
Authors: | Larissa S Melanchauski Ana Paula G S Broto Thiago M Moraes Ana Lúcia M Nasser Ataa Said Usama W Hawas Khaled Rashed Wagner Vilegas Clélia A Hiruma-Lima |
| |
Institution: | 1.S?o Paulo State University-UNESP,Botucatu,Brazil;2.S?o Paulo State University-UNESP,Araraquara,Brazil;3.Pharmacognosy Department,National Research Centre,Giza,Egypt;4.Phytochemistry and Plant Systematic Department,National Research Centre,Giza,Egypt |
| |
Abstract: | Ailanthus excelsa (Roxb), an Egyptian medicinal species highly important for treating numerous diseases, was investigated against experimentally
induced gastric ulcer in rodents. We evaluated the gastroprotective effect of four extracts (petroleum ether, diethyl ether,
chloroform, and methanol) of A. excelsa bark by using the ethanol-induced gastric lesion model. The pretreatment of animals with methanolic, petroleum ether, and
chloroformic extracts (100 mg/kg, oral (p.o.)) from A. excelsa significantly reduced gastric lesion induced by ulcerogenic agent (56, 47, and 70%, respectively) when compared with animals
pretreated with vehicle. However, the diethyl ether pretreatment led to the least gastric lesion damage (83%), similar to
the standard antiulcer drug, cimetidine, at the same dose (100 mg/kg, p.o.). The lower effective dose of diethyl ether extract,
as well as cimetidine, given by intraduodenal route, significantly increased the pH values and reduced the acid output of
gastric juice. Sterols, triterpenes, and quassinoids are present in the diethyl ether extract of A. excelsa stem bark, which presented the best gastroprotective action among the studied extracts. Our study confirmed the traditional
indications of A. excelsa for the treatment of gastric ulcer. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|