| 基质金属蛋白酶及其抑制剂与鼻咽癌的侵袭性的关系 |
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| 引用本文： | 冯海燕,黄光武,唐安洲,徐志文. 基质金属蛋白酶及其抑制剂与鼻咽癌的侵袭性的关系[J]. 中国耳鼻咽喉颅底外科杂志, 2003, 9(5): 286-289 |
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| 作者姓名： | 冯海燕 黄光武 唐安洲 徐志文 |
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| 作者单位： | 1. 广西医科大学附属第五医院,耳鼻喉科,广西,柳州,545001
2. 广西医科大学附属第一医院,耳鼻喉科,广西,南宁,530021 |
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| 摘 要： | 目的研究基质金属蛋白酶-2,9(matrix metalloproteinase-2,9,MMP-2,9)及组织基质金属蛋白酶抑制剂-1,2(timue inhibitors of the MMP-1,2,TIMP-1,2)与鼻咽癌侵袭的关系。方法用免疫组化S-P法,检测48例鼻咽癌组织及16例鼻咽炎组织中MMP-2,MMP-9,TIMP-1,TIMP-2的表达。结果 鼻咽癌与鼻咽炎两组病人TIMP-1,TIMP-2比较有统计学意义(P<0.01),随着鼻咽癌原发灶T分期的发展,TIMP-1有增加的趋势。结论TIMP-1可以作为监测鼻咽癌侵袭的参数之一。
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| 关 键 词： | 基质金属蛋白酶 组织基质金属蛋白酶抑制剂 鼻咽肿瘤 病理学 肿瘤浸润力 鼻咽癌 侵袭性 |
| 文章编号： | 1007-1520(2003)05-0286-04 |
| 修稿时间： | 2002-11-25 |
Relationship of MMP-2, 9 and TIMP-1, 2 with the invasion and metastasis of nasopharyngeal carcinoma |
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| FENG Hai-yan,HUANG Guang-wu,TANG An-zhou,et al.. Relationship of MMP-2, 9 and TIMP-1, 2 with the invasion and metastasis of nasopharyngeal carcinoma[J]. Chinese Journal of Otorhinolaryngology-skull Base Surgery, 2003, 9(5): 286-289 |
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| Authors: | FENG Hai-yan HUANG Guang-wu TANG An-zhou et al. |
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| Abstract: | Objective To investigate the relationship between the expression of matrix metalloproteinase-2, 9 (MMP-2, MMP-9), tissue inhibitor of matrix metalloproteinases-1, 2 (TIMP-1, TIMP-2) and the invasion and metastasis of nasopharyngeal carcinoma (NPC). Methods MMP-2, MMP-9, TIMP-1, and TIMP-2 protein expression in 48 NPC patients and 16 patients with nasopharyngeal mucositis were studied by immunohistochemical method. Results TIMP - 1 , TIMP - 2 protein expressions between the NPC and the nasopharyngeal mucositis were positively correlated ( P <0.05). With the progression of the primary region of NPC, the expression of TIMP-1 tended to increase. Conclusion The expression of TIMP-1 protein may be regarded as a sign of the progression of NPC. |
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| Keywords: | Matrix metalloproteinases (MMPs) Tissue inhibitors of matrix metalloproteinases (TIMPs) Nasopha-ryngeal neoplasms/nathor Neoplosm invasireness |
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