影响鼻咽癌预后的相关因素分析

目的：回顾性分析鼻咽癌患者临床资料，探讨影响鼻咽癌预后的相关因素。方法总结2006年1月1日－2012年9月1日就诊于南京军区福州总医院的1286例鼻咽癌患者的病理类型、血清EBV-IgA检测结果、年龄、性别、T分期、N分期、治疗方式、复发、远处转移等临床资料，并随访其生存率。用Kaplan-Meier法进行生存分析，Log-Rank法检验组间生存率差异。 Cox回归模型进行多因素分析。结果单因素分析结果显示，T分期、N分期、临床分期是影响鼻咽癌的预后因素（ P＜0．05），而性别、病理类型、血清EBV-IgA阳性、治疗方式等对预后无明显影响（P＞0.05）。多因素分析结果显示，年龄、T分期、N分期、治疗方式是影响鼻咽癌预后的独立危险因素（P＜0．05）。结论年龄、T分期、N分期、治疗方式是影响鼻咽癌预后的独立危险因素。 T分期、N分期、临床分期越晚，预后越差，综合治疗比单纯放疗预后好，性别、病理类型、血清EBV-IgA阳性对鼻咽癌预后无明显影响。

Analysis of factors related to the NPC patients'prognosis

Objective To investigate the factors related to the NPC patients＇prognosis .Methods Clinical data of 1286 NPC patients received treatment in Fuzhou General Hospital of Nanjing Military Command from Jan 1,2006 to Sep 1,2012 were studied ret-rospectively.The data included pathological types ,results of serum EBV-IgA,age,T stage,N stage,treatment methods,recurrence and metastasis ,and the patients＇survival condition .Kaplan-Meier was used to survival analysis and Log-Rank was used to test the difference of survival rate among the study groups respectively .In addition,Cox regression mode was used for multiple factors analysis .Results Single factor analysis showed that T stage , N stage and clinical stage were statistical difference in the influence on prognosis （ P 〈0.05）,while the gender,pathological types and positive rate of serum EBV-IgA were not（P〉0.05）.Multiple factor analysis exhibited that the age,T stage,N stage,clinic stage and treatment methods were statistical different in the influence on prognosis （P〈0.05）. Conclusion It was found that the age ,T stage,N stage,treatment were significant correlation with the prognosis of nasopharyngeal car-cinoma by multivariate study.The later the T,N stage were,clinical stage,the worse the prognosis were.The comprehensive treatment is better than radiotherapy alone .