Plant polyphenols attenuate hepatic injury after hemorrhage/resuscitation by inhibition of apoptosis, oxidative stress, and inflammation via NF-kappaB in rats |
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| Authors: | Borna Relja Eva Töttel Lara Breig Dirk Henrich Heinz Schneider Ingo Marzi Mark Lehnert |
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| Affiliation: | (1) Department of Trauma, Hand and Reconstructive Surgery, Hospitals of the Goethe-University Frankfurt am Main, 60590 Frankfurt, Germany;(2) HealthEcon AG, 4051 Basle, Switzerland |
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| Abstract: | Purpose Oxidative stress and inflammation contribute to hepatic injury after hemorrhage/resuscitation (H/R). Natural plant polyphenols, i.e., green tea extract (GTE) possess high anti-oxidant and anti-inflammatory activities in various models of acute inflammation. However, possible protective effects and feasible mechanisms by which plant polyphenols modulate pro-inflammatory, apoptotic, and oxidant signaling after H/R in the liver remain unknown. Therefore, we investigated the effects of GTE and its impact on the activation of NF-kappaB in the pathogenesis of hepatic injury induced by H/R. |
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