肿瘤血管生成与超声造影成像相关性研究进展

血管生成是恶性肿瘤的重要特征,微血管密度是评价肿瘤血管生成的金标准,且与肿瘤的分级有很好的相关性。超声造影成为目前评价肿瘤血管的最新检查方法,可通过测定各种灌注参数对活体肿瘤组织的微血管生成情况进行判断。不仅可以为临床提供术前更加丰富的病理学及病理生理学信息。同时其反映肿瘤血管的指标与肿瘤微血管密度具有较高的相关性,从而为预测预后及抗肿瘤血管生成的疗法、手术切除等治疗方案的选择提供重要的依据。

Advances of correlations between tumor angiogenesis and contrast-enhanced ultrasound

Angiogenesis is the character of malignant tumors, microvascular density is not only the gold standard to evaluate tumor angiogenesis, but also correlative with tumorous grade. Contrast-enhanced ultrasound is one of the latest methods to evaluate tumor angiogenesis at present, which can evaluate in vivo angiogenesis by mensuring perfusion parameters. It can offer preoperative pathology and pathophysiology information to clinic. Furthermore, the index-evaluated angiogenesis has a significant correlation with microvascular density. So contrast-enhanced ultrasound can help predict prognosis and select treatment plan of anti-angiogenic therapy and exairesis et al.