茶多酚对Lewis肺癌的生长抑制、抗氧化及免疫调节作用的研究

目的：研究茶多酚对小鼠肺癌的生长抑制、抗氧化及免疫调节作用。方法：以接种Lewis肺癌的C57BL/6J小鼠为模型，灌服茶多酚。结果：125 mg/kg， 250 mg/kg组抑瘤率分别为27.2%，18.8%，前者与荷瘤对照组比较有显著差异(P<005）。接种Lewis肺癌后的小鼠，胸腺重量及其指数减轻，脾指数增高，血清MDA含量明显增高，对SOD，GSHPx活性影响不明显。茶多酚可显著降低荷瘤小鼠血清MDA含量，提高SOD，GSHPx活性。同时降低其胸腺指数和脾指数，表现出免疫抑制。结论：茶多酚可抑制Lewis肺癌生长，其抗癌作用机制与抗氧化作用有关。

Effects of Polyphenol(TP) on Growth Inhibition,Anti-Oxidation and Immune Regulation of Lewis Lung Cancer in Mice

Objective: To investigate the effects of Tea Polyphenol(TP) on inhibition of tumor growth, anti-oxidation and immune regulation in tumor-bearing mice. Methods: TP was administered by gastriclavage to C57BL/6J mice implanted with Lewis lung cancer. Results: Inhibitory rates of TP at doses of 125 mg/kg and 250 mg/kg were 27.2% and 18.8% respectively, with significance over controls at dose of 125 mg/kg( P <0.05). In tumor-bearing mice, weight of thymus and its index were declined and spleen index was increased, while serum MDA levels were increased significantly at the same time, SOD and GSH-Px activities had no change after mice were beard tumor. Serum MDA levels of tumor-bearing mice were decreased significantly and SOD and GSH-Px activities were increased by TP. Thymus index and spleen index were decreased at the same time. Conclusion: TP could inhibit the growth of Lewis lung cancer, the underlying mechanism of which was associated with anti-oxidation.