S100B蛋白在癫痫患儿血清中的表达及其临床意义

目的探讨SIOOB蛋白在癫痫患儿血清中的表达及其临床意义。方法选择绍兴市人民医院2010年2月1013年3月收治的癫痫患儿208例作为病例组，其中全身性发作（GSEP）87例，部分性发作（FSEP）121例。同期体检健康儿童135例作为对照组，采用酶联免疫吸附法（ELISA）检测正常儿童及癫痫患儿发作后4h和24h血清S100B蛋白水平。结果正常儿童血清S100B蛋白呈现偏态分布，与年龄呈负相关；癫痫组患儿发作4h后血清S100B蛋白水平较正常儿显著升高（P〈0．05），且GSEP组水平显著高于FSEP组（P〈0．05）；癫痫组患儿发作后24h血清S100B蛋白水平较发作后4h显著下降（P〈0．05），高于正常儿童，但差别无统计学意义（P〉0．05），GSEP组与FSEP组问差别亦无统计学意义（P〉0．05）。结论癫痫发作早期脑损伤明显，严重程度与发作类型密切相关，但恢复较快。血清S100B可作为判断癫痫患儿神经损伤程度的敏感指标。

Clinical value of serum S100B in children with epilepsy

Objective To evaluate the clinical value of serum S100B protein in children with epilepsy. Methods 208 children with epilepsy, including 87 cases of generalized seizures and 121 cases of partial seizures, and 135 health children（ physical examination） in our hospital from Feb. 2010 to Mar. 2013 were recruited. The serum levels of S100B on different time points（tI =4 h,t2 =24 h） were tested by ELISA. Results The serum S100B in the control group demon- strated skewed distribution with negative correlation of age. The S100B serum level in the experiment group at t1 was much higher than that in the control group（ P 〈 0.05 ） , and in generalized seizures group was significant higher than that in partial seizures group（ P 〈0.05 ） ;The serum S100B level in the experiment group at t2 was significant decreased compared with that at t1 （P 〈 0.05 ） , there was no statistical difference between generalized seizures group and partial seizures group （ P 〉 0.05 ）. Conclusion The obviously nerve damage can be found in the early stage of epilepsy seizures, which is correlated with the type of seizures. The serum S100B level can be used as a sensitivity index for the evaluation of the nerve damage in children with epilepsy.