基质金属蛋白酶2及CD147在卵巢上皮性肿瘤中的表达

目的：了解基质金属蛋白酶（MMP－2）及CD147在卵巢良、恶性上皮性肿瘤中的表达，探讨其与卵巢癌转移发生的关系。方法用免疫组化SP法对47例卵巢癌组织、19例交界性上皮性卵巢肿、17良性上性卵巢肿瘤组织中MMP－2及CD147的表达情况进行了检测。结果MMP－2在恶性及交界性上皮性卵巢肿瘤中的强阳性表达率分别为59％，42％，明显高于良性组织阳性表达率30％（P＜0．05），在卵巢癌中MMP－2的表达与卵巢癌的临床分期有关，Ⅲ=-Ⅳ期卵巢癌强阳性表达率71％，明显高于Ⅰ-Ⅱ期卵巢癌强阳性表达率375（P＜0．05），与分化程度无明显关联，但有淋巴细胞转移的病例强阳性表达率87％，明显高于无淋巴结转移组，CD147在恶性及交界卵巢上皮性肿瘤中的强阳性表达率分别为为64％，57％，而良性组则未见CD147的表达，在卵巢癌中，CD147的强旨性表达率与临床分期有前，Ⅲ-Ⅳ期的癌组织强阳性表达率74％，明显高于Ⅰ-Ⅱ期强阳性表达率45％，在不同分化程度卵巢癌组织中CD147的强阳性率无明显差异，有无淋巴结转移的卵巢癌组织中CD147强阳性表达率差异显著，结论MMP－2及CD147均与卵巢癌的分期及淋巴结转移有关，CD147与MMP－2的产生关系密切。

Expression of matrix metalloproteinase-2 and CD147 in ovarian epithelial tumor

AIM　To investigate the expression of matrix metall oproteinase-2 (MMP-2) and CD147 in ovarian epithelial tumor. METHODS　The expression o f MMP-2 and CD147 was detected in malignant, borderline and benign ovarian tissues by immunohistochemical SP method. Monoclonal antibodies against MMP-2 and CD147 were used. RESULTS　Intense expression rates o f MMP-2 in the malignant, borderline, benign epithelial tumor tissues of ovary was 59%, 42%, 30% respectively, There were a significant difference between malignant, borderline and benign tumors (P<0.05). In ovarian cancer, th e expression of MMP-2 had a significant relevance to clinical phases and lymph node metastasis. The intense expression rate (71%) in phases Ⅲ～Ⅳ of ovarian cancer was much higher than that in phases Ⅰ～Ⅱ (37%); no relevance was obser ved with pathological grades. The intense expression rates of CD147 in the malignant, borderline, benign ovarian epithelial tumor were 64%, 57%, 0 respect ively. Significant difference was observed between malignant, borderline and benign ovarian epithelial tumor. In ovarian cancer, the expression of CD147 wa s associated with clinical phases; the intense expression rate (74%) in phases Ⅲ ～Ⅳ of ovarian cancers was much higher than that in phases Ⅰ～Ⅱ (45%). 18 of 23 ca ses with lymph node metastasis had intense expression of CD147, while only 12 of 24 cases without lymph node metastasis had intense staining of CD147. No association was observed with pathological grades. CONCLUSION　Both MMP-2 and C D147 have relevance to clinical phases and lymph node metastasis of ovarian cancer, but CD 147 isn't the unique factor in increasing the expression of MMP-2 to contribute to the metastasis of ovarian cancer.