Granulomatous hepatitis,perihepatic lymphadenopathies,and autoantibody positivity: an unusual association in a child with hepatitis C |
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Authors: | Odul Egritas Sinan Sari Buket Dalgic Cigdem Vural Gulen Akyol |
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Institution: | (1) Department of Pediatric Gastroenterology, Gazi University School of Medicine, Ankara, Turkey;(2) Department of Pathology, Gazi University School of Medicine, Ankara, Turkey |
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Abstract: | A 10-year-old boy with hepatitis C had granulomatous hepatitis (GH) at initial liver biopsy. He also had enlarged perihepatic
lymph nodes and smooth muscle antibody (SMA) positivity. GH is a rare finding in hepatitis C virus (HCV) infection. Our patient
is special since GH secondary to HCV infection was associated with both autoantibodies and multiple intraabdominal lymphadenopathies.
After interferon (IFN) and ribavirin therapy, HCV RNA became negative, along with the resolution of hepatic granulomas (HG),
lymphadenopathies, and SMA positivity. Although early virologic response was not achieved under IFN treatment, the therapy
period was extended, contrary to routine practice, and resulted in a delayed response. We conclude that the usage of IFN for
longer periods in GH-associated HCV infection might be promising. |
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Keywords: | Hepatitis C Granulomatous hepatitis Perihepatic lymphadenopathy Autoantibody |
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