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海藻酸钙凝胶微丸作为口服缓释给药载体的研究
引用本文:马萍,祝力,孙淑英,辛艳茹,杨京燕.海藻酸钙凝胶微丸作为口服缓释给药载体的研究[J].沈阳药科大学学报,2001,18(6):406-408.
作者姓名:马萍  祝力  孙淑英  辛艳茹  杨京燕
作者单位:1. 第二炮兵总医院药剂科
2. 沈阳药科大学药学院
摘    要:将海藻酸钠溶液滴入胶凝剂氯化钙溶液中制备了海藻酸钙凝胶微丸。以胶凝过程中凝胶微丸重量变化 (失水量 )研究了胶凝速率及不同浓度海藻酸钠溶液 ( 1 %~ 4 % )与氯化钙溶液 ( 0 0 5~0 2 0mol/L)对胶凝速率的影响 ,结果是 6h前胶凝速率快 ,随后减慢 ,约 70h胶凝完全 ,氯化钙溶液的浓度≥ 0 1mol/L对胶凝速率无明显影响。干燥的凝胶微丸在不同水性介质中溶胀试验结果表明 :在温度约 37℃时 ,微丸在蒸馏水和 0 1mol/L盐酸 ( pH1 0 )中几乎不溶胀 ,而在磷酸盐缓冲溶液( pH6 8)中1h溶胀 ,溶胀后的微丸直径是干燥前湿微丸直径的 1 80 %。海藻酸钙凝胶微丸这种溶胀的 pH敏感性 ,使它能成为口服药物缓释制剂的载体。以硝苯地平为模型药物制备的海藻酸钙凝胶微丸 ,其体外释放试验结果 ,2h累积释放量为 2 0 %~ 30 % ,6h为 6 0 %~ 80 % ,1 2h时大于85 %。药物从微丸中的释放是以扩散和骨架溶蚀相结合的方式。由此可见 ,硝苯地平的海藻酸钙凝胶微丸具有缓释作用

关 键 词:海藻酸钙凝胶微丸  胶凝速率  溶胀性  硝苯地平  释放度
文章编号:1006-2858(2001)06-0406-03
修稿时间:2001年4月5日

Study on calcium alginate gel beads as oral drugs administration carriers
MA Ping ,ZHU Li ,SUN Shu ying ,XIN Yan ru ,YANG Jing yan.Study on calcium alginate gel beads as oral drugs administration carriers[J].Journal of Shenyang Pharmaceutical University,2001,18(6):406-408.
Authors:MA Ping  ZHU Li  SUN Shu ying  XIN Yan ru  YANG Jing yan
Institution:MA Ping 1,ZHU Li 2,SUN Shu ying 2,XIN Yan ru 1,YANG Jing yan 1
Abstract:Ca alginate gel beads were prepared by dropping Na alginate solution into CaCl 2 solution.The gelation rate of the beads were measured in terms of weight changes.The effect of Na alginate concentration (1%~4%) and CaCl 2 solution concentration( 0 05 ~ 0 20 mol/L ) on the gelation rate were studied.The result indicated a rapid initial decrease and a subsequnent slow stage and the higher CaCl 2 solution concentration( ≥0 1 mol/L ) was not obvious.The swelling property of the dried beads from fully cured hydrogels was studied.It should be noted here that no swelling was observed in the distilled water and 0 1 mol/L HCl(pH 1 0) solution,while in phosphate buffer (pH 6 8) the dried beads swelled to the diameter 180% as long as its original diameter before being dried.Such a pH sensitive swelling property could be advantageous to orally administered drug vehicles.Nifedipine (NP) sustained release beads were prepared with calcium alginate as a carrier.The release amount of NP from the beads in vitro was 20%~30% at 2 h ,60%~80% at 6 h ,greater than 85% at 12 h .The NP release from the gel beads followed the mechanism of diffusion and erosion.
Keywords:calcium alginate gel beads  gelation rate  swelling property  nifedipine  release rate
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