| 普疏舒对血小板聚集功能的影响 |
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| 引用本文： | 刘赛,王春波,张鲁平,阎应举.普疏舒对血小板聚集功能的影响[J].青岛大学医学院学报,1993(2). |
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| 作者姓名： | 刘赛 王春波 张鲁平 阎应举 |
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| 作者单位： | 青岛医学院药理学教研室
(刘赛，王春波)，青岛市第二人民医院
(张鲁平)，青岛医学院药理学教研室(阎应举) |
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| 摘 要： | 本文观察了普疏舒对大白鼠血小板聚集功能的影响。结果表明,连续灌胃给予普疏舒(105.8mg/kg和282.2mg/kg)对牛凝血酶诱导的大鼠血小板聚集有明显抑制作用,抑制率分别为0.86和0.67(P<0.01)。同样剂量的普疏舒亦可使ADP诱导的血小板聚集率降低0.67和0.44(P<0.01)。提示普疏舒具有对抗血小板聚集的作用。
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| 关 键 词： | 普疏舒 血小板凝集 凝血酶类 腺苷二磷酸 大鼠 近交系 |
EFFECT OF POLY-SECCHARIDE SULPHATE COMPOSTITUS ON PLATELET AGGREGATION IN RATS |
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| Liu Sai,Wang Chunbo,Zhang Luping,et al.EFFECT OF POLY-SECCHARIDE SULPHATE COMPOSTITUS ON PLATELET AGGREGATION IN RATS[J].Acta Academiae Medicinae Qingdao Universitatis,1993(2). |
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| Authors: | Liu Sai Wang Chunbo Zhang Luping |
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| Institution: | Liu Sai,Wang Chunbo,Zhang Luping,et al Department of Pharmacology |
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| Abstract: | The effects of Poly-Saccharide Sulfate Compositus (COP) on platelet aggregation in
rats were studied by the optical method. COP at the dosages of p. o. 105.8mg/kg and
282.2mg/kg markedly inhibited platelet aggregation induced by thrombin. The inhibi-
tion rates were 0.86 and 0.67 respectively. COP also depressed the maximal aggregative
response of platelets to ADP, with inhibition rates of 0.67 and 0.44 respectively. |
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| Keywords: | poly-saccharide sulphate compositus platelet aggregation thromnbin adenosine diphosphate rats inbred strains |
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