| 急性胰腺炎患者血清抗坏血酸水平及维生素C辅助治疗的临床研究 |
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| 引用本文： | 蔡笃雄,陈卫昌,温晓持,许春芳,石建,缪丽燕.急性胰腺炎患者血清抗坏血酸水平及维生素C辅助治疗的临床研究[J].苏州大学学报(自然科学版),2006,26(1):78-80,91. |
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| 作者姓名： | 蔡笃雄 陈卫昌 温晓持 许春芳 石建 缪丽燕 |
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| 作者单位： | [1]苏州大学附属第一医院消化科,江苏苏州215006 [2]苏州大学附属第一医院药剂科,江苏苏州215006 [3]现在海南医学院附属医院消化内科,江苏苏州215006 |
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| 摘 要： | 目的探讨血清抗坏血酸（AA）水平变化与急性胰腺炎（AP）及其严重程度的关系及维生素C对重症急性胰腺炎（SAP）的辅助治疗作用。方法患者40例，其中轻型急性胰腺炎（MAP）24例，SAP16例，将患者分为治疗组及对照组．治疗组加用维生素C2g稀释于5％葡萄糖液500ml中静滴．每日1次，连用7d，对照组不用维生素C。另取10名健康体检者为正常对照组。分别检测正常对照组和患者入院时血清AA及C．反应蛋白（CRP）．SAP对照组及治疗组另外分别在入院第2、3、7天检测血清AA，并观察两组SAP患者腹痛、发热症状消失时间。血淀粉酶恢复正常时间及住院天数。结果AP患者与正常对照组相比，血清AA明显降低（P〈0．01），CRP明显升高（P〈0．01）；SAP患者与MAP患者相比，血清AA显著降低（P〈0．01）．CRP显著升高（P〈0．01）；SAP治疗组入院第2、3、7天血清AA均较对照组显著升高（P〈0．05），SAP治疗组患者体温、血淀粉酶恢复正常时间及住院时间均较对照组明显缩短（P〈0．05）。结论AP患者血清AA明显降低，且其降低程度与AP的严重程度相关，给予维生素C治疗能明显提高SAP患者血清AA水平，对SAP可能具有辅助治疗作用。
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| 关 键 词： | 急性胰腺炎 抗坏血酸 氧自由基 |
| 文章编号： | 1673-0399（2006）01-0078-03 |
| 收稿时间： | 2005-02-02 |
| 修稿时间： | 2005-02-02 |
An Clinical Study of Plasma Ascorbic Acid Level and the Minor Therapy of VitaminC in Patient with Acute Pancreatitis |
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| CAI Du-xiong, CHEN Wei-chang, WEN Xiao-chi, et al.An Clinical Study of Plasma Ascorbic Acid Level and the Minor Therapy of VitaminC in Patient with Acute Pancreatitis[J].Suzhou University Journal of Medical Science,2006,26(1):78-80,91. |
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| Authors: | CAI Du-xiong CHEN Wei-chang WEN Xiao-chi |
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| Institution: | Dept of Gastroenterology, the First Hospital Affiliated to Suzhou University, Jiangsu Suzhou 215006, China |
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| Abstract: | Objective To investigate the changes of plasma ascorbic acid(AA) level and the minor therapy of VitC in patient with acute pancreatitis(AP).Methods Fourty cases of AP were divided into 24 cases of mild acute pancreatitis(MAP) and 16 cases of severe acute pancreatitis(SAP),and the SAP was divided into the treated group and the control group,10 healthy cases were taken as the normal group.VitC(2 g/d) was given intravenously for 7 days in the VitC treated group,but not in the control group.The level of serum AA and Creactive protein(CRP) was measured in the normal group and the pantients with AP when they were admitted to hospital firstly.In addition,the level of serum AA was measured in the SAP treated group and the control group in 2,3,7 day after admission,time of abdominal pain,body temperature,serum amylase returing to normal levels and hosipital stay were observed in the SAP treated group and the control group.Results Compared with normal group,the level of serum AA significantly decreased(P<0.01)and serum CRP significantly increased(P<0.01) in the pantients with AP.The level of serum AA significantly decreased(P<0.01) and serum CRP significantly increased(P<0.01) in the pantients with SAP compared the patients with MAP.Compared with SAP control group,the level of serum AA significantly increased in the treated SAP group in 2,3,7 day after admission(P<0.05),the time of body temperature and serum amylase returing to |
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| Keywords: | pancreatitis ascorbic acid oxygen free radicals |
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