| 促进药物跨血脑屏障转运载体的研究进展 |
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| 引用本文： | 宋必卫,王文喜,牛泱平.促进药物跨血脑屏障转运载体的研究进展[J].中国药理学通报,2005,21(10):1167-1170. |
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| 作者姓名： | 宋必卫 王文喜 牛泱平 |
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| 作者单位： | 浙江工业大学药学院,浙江杭州310014 |
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| 基金项目： | 国家自然科学基金资助项目（No.30470610） |
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| 摘 要： | 血脑屏障(BBB)主要由脑毛细血管内皮细胞构成,其阻止98%小分子和几乎全部大分子化合物入脑,是制约脑药发展的重要因素。目前将药物递送入脑的主要途径为神经外科学、药化和生理学途径,后者利用脑毛细血管内皮细胞膜受体介导的跨细胞系统(RMT)为载体携载药物经主动转运入脑。基于RMT可构建促进药物入脑的载药平台,该文重点介绍该平台的研究思路、方法技术和应用前景等方面的最新研究进展。
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| 关 键 词： | 血脑屏障 转铁蛋白受体 载体 |
| 文章编号： | 1001-1978（2005）10-1167-04 |
| 收稿时间： | 2005-06-28 |
| 修稿时间： | 2005-08-21 |
Progress in the vector-mediated drug delivery system to the brain |
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| SONG Bi-wei,WANG Wen-xi, NIU Yang-ping.Progress in the vector-mediated drug delivery system to the brain[J].Chinese Pharmacological Bulletin,2005,21(10):1167-1170. |
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| Authors: | SONG Bi-wei WANG Wen-xi NIU Yang-ping |
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| Institution: | Dept of Pharmacology, College of Pharmaceutical Science, Zhejiang University of Technoloy, Hangzhou 310014, China |
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| Abstract: | The blood-brain barrier(BBB) is formed by the brain capillary endothelium and excludes from the brain approximately 100% of large-molecule neurotherapeutics and more than 98% of all small-molecule drugs.There are three routines to increase drug transport into brain,ie,neurosurgical,pharmaceutical chemical,and physiological ways and the later is most hopeful.The receptor-mediated transcytosis system on the brain capillary endothelium could be used as multifunctional vectors for drug active transport into brain.This provides the platform for CNS drug delivery programs. |
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| Keywords: | blood-brain barrier Transferring receptor vector |
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