| 热性惊厥患儿一氧化氮、一氧化氮合成酶及脑电图的临床分析 |
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| 引用本文： | 尹丽娟,王开霞.热性惊厥患儿一氧化氮、一氧化氮合成酶及脑电图的临床分析[J].华北煤炭医学院学报,2007,9(5):609-611. |
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| 作者姓名： | 尹丽娟 王开霞 |
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| 作者单位： | 华北煤炭医学院附属医院儿科,河北唐山,063000 |
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| 摘 要： | ①目的 探讨热性惊厥患儿血清和脑脊液一氧化氮（NO）及其合成酶（NOS）的含量及其与热性惊厥发病机制和脑损伤的关系.②方法 分别采用硝酸还原酶法、酶测定法测定患儿血清和脑脊液中NO、NOS的含量.应用定量数字视频脑电图仪检测脑电图.③结果 热性惊厥组脑脊液中NO水平与NOS活性均明显低于时照组（P＜0.05）.④结论 热性惊厥发作可引起血清和脑脊液中NO水平明显低于对照组,提示NO可能参与抗惊厥机制及可能具有抗惊厥作用.
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| 关 键 词： | 惊厥 热性 一氧化氮 一氧化氮合成酶 |
| 文章编号： | 1008-6633（2007）05-0609-03 |
| 修稿时间： | 2007-04-23 |
Clinical analysis of nitric oxide, nitric oxide synthase and electroencephalograph in infants with febrile convulsion |
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| YIN Lijuan,WANG Kaixia.Clinical analysis of nitric oxide, nitric oxide synthase and electroencephalograph in infants with febrile convulsion[J].Journal of North China Coal Medical College,2007,9(5):609-611. |
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| Authors: | YIN Lijuan WANG Kaixia |
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| Institution: | Department of Pediatric of Affiliated Hospital of North China Coal Medical College, Tangshan 063000, China |
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| Abstract: | Objective To investigate the levels of nitric oxide(NO) and nitric oxide synthase(NOS) of cerebrospinal fluid and serum in infants with febrile convulsion,and study the relation between febrile convulsion mechanism and brain injury.Methods The levels of NO and NOS in cerebrospinal fluid and serum were measured by nitric acid reduction enzyme method and enzyme measured method respectively.Results NO levels and NOS activity of cerebrospinal fluid in febrile convulsion group were singnificantly lower than those in control group(P<0.05).Conclusion The level of NO in cerebrospinal fluid and serum was singnificantly lower than that in control group.No may participate in anti-convulsion mechanism and play a role in anti-convulsion. |
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| Keywords: | Convulsion Febrile Nitric oxide Nitric oxide synthase |
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