| 皮质酮对体外培养的大鼠海马神经元膜电位的影响 |
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| 引用本文： | 马强,刘卫.皮质酮对体外培养的大鼠海马神经元膜电位的影响[J].中国神经科学杂志,2000,16(2):123-125. |
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| 作者姓名： | 马强 刘卫 |
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| 作者单位： | [1]军事医学科学院卫生学环境医学研究所 [2]军事医学科学院药物毒物研究所 |
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| 摘 要： | 为探讨应激激素－皮质酮以违法乱纪 马神经细胞膜电位的影响，采用膜片钳全细胞记录的方法，测量了原代培养的大鼠马神经细胞膜的静脉电位。结果发现，在皮质酮的作用下，海马神经静息电位幅值明显降低，细胞膜呈去极化。
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| 关 键 词： | 应激 皮质酮 海马神经细胞 静息电位 大鼠 |
Effect of corticosterone on the membrane potential of cultured rat hippocampal cell in vitro |
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| MA Qiang,LIU Wei,WU Li ying,CHAO Fu huan.Effect of corticosterone on the membrane potential of cultured rat hippocampal cell in vitro[J].Neuroscience Bulletin,2000,16(2):123-125. |
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| Authors: | MA Qiang LIU Wei WU Li ying CHAO Fu huan |
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| Abstract: | To probe the effect of stress hormone corticosterone on the hippocampal cell membrane potential,the resting potentials of rat hippocampal cells in primary culture were measured with the patch clamp whole cell recording.The results showed that the amplitudes of resting potentials in hippocampal cells decreased and the membrane depolarized under the corticosterone.It is speculated that the normal energy metabolic process in hippocampal neurons may be disturbed by the corticosterone.Consequently, the cell membrane depolarized. |
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| Keywords: | stress corticosterone(CORT) hippocampal neuronal cell resting potential(RP) |
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