Hippocampal expression of the calcium sensor protein visinin-like protein-1 in schizophrenia |
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Authors: | Bernstein Hans-Gert Braunewell Karl-Heinz Spilker Christina Danos Peter Baumann Bruno Funke Sieglinde Diekmann Silvia Gundelfinger Eckart D Bogerts Bernhard |
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Institution: | Department of Psychiatry of the University Magdeburg, Leipziger Str. 44, D-39120, Germany. |
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Abstract: | Hippocampal cytoarchitectural abnormalities may be part of the cerebral substrate of schizophrenia. Amongst the chemical components being abnormal in brains of schizophrenics are altered calcium concentrations and reduced expression of the neurotrophin receptor, trkB. We studied by immunohistochemical methods the distribution of visinin-like protein-1 (VILIP-1), which is a calcium sensor protein and at the same time a trkB mRNA binding protein, in hippocampi of nine schizophrenic patients and nine matched control subjects. In normal hippocampi VILIP-1 immunoreactivity was found in multiple pyramidal cells and interneurons. A portion of VILIP-1 immunoreactive interneurons co-express calretinin (60%) and parvalbumin (<10%). In schizophrenics fewer pyramidal cells but more interneurons were immunostained. Our data point to an involvement of the protein in the altered hippocampal circuitry in schizophrenia. |
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