Complete genomic characterization and antigenic relatedness of genogroup III,genotype 2 bovine noroviruses |
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Authors: | S L Oliver E Asobayire A Charpilienne J Cohen J C Bridger |
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Institution: | (1) Department of Pathology and Infectious Diseases, Royal Veterinary College, London, U. K.;(2) Unité Mixte de Recherche CNRS-INRA, Virologie Moléculaire et Stucturale, Gif-sur-Yvette, France |
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Abstract: | Summary. Bovine enteric noroviruses form a genogroup, III, distinct from the 2 human norovirus genogroups, I and II. Two genogroup
III genotypes were suggested by partial genomic analyses. In the present study, analysis of the full-length genome sequence
of Bo/Newbury2/76/UK and the more contemporary Newbury2-like virus, Bo/Dumfries/1994/UK, showed that both were 7311 nucleotides
in length and had three open reading frames (ORFs), amino acids motifs typical of noroviruses, and 95% or greater amino acid
identities to each other in all regions of their genome. Apart from the ORF1 NTPase region, their ORF1 regions had less than
90% identity to the genogroup III genotype 1 Bo/Jena/80/DE virus, confirming two genogroup III genotypes. A close antigenic
relationship was demonstrated by ELISA between the genotype 2 viruses, which will allow their serological diagnosis.
Deceased Fourth Author] |
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