胃癌患者血清及癌组织中硒含量的对比研究

作者对30例胃癌患者血清硒含量及其中18例胃癌组织样本硒含量的研究发现:胃癌患者的血清硒含量远远低于健康人(P<0.001),而癌组织样本的硒含量却明显高于同源正常胃壁组织(P<0.01),关于胃癌组织中硒含量测定目前报告甚少。作者认为:(1)人群中血清硒水平与胃癌的发生呈负相关。这同目前的大多数报道相同。(2)胃癌患者癌组织中硒含量高于正常胃壁表明,硒有肿瘤的趋向性和浓集现象,这给补硒抗癌研究提供了乐观的前景,对进一步研究补硒时机、补硒利弊、补硒途径及补硒量都有帮助。(3)胃癌病人硒的分布特点可能会更加导致血清硒的降低。(4)作者提醒大家注意:少数胃癌患者血清晒含量接近正常值,所以一定要注意假阴性结果的出现,甚至发生误诊。

A Comparative study on selenium content in sera and tumor tissues of patients with stomach cancer

In this report, 30 patients with stomach cancer were selected to measure the serum selenium level, and tumor samples were obtained from 18 cases of them to measure the selenium content in tumor tissues. The result showed that the serum selenium level of the patients was much lower than that of healthy control ( P <0. 001) , and the selenium content in tumor tissues was much higher than that in normal tissues ( P <0. 01). By now, there have been few reports about the measurement of selenium content in stomach carcinomas tissues. According to our re-sults, the author suggests that: (1) A negative correlation is showed between the serum selenium level and the occurrence of stomach carcinoma, which is consistent with the results of most recent reports. (2) selenium content in stomach carcinoma tissues is higher than that in normal tissues. This result indicates a tumor tropism an accumulation phenomenon of selenium, which brings out an optimistic prospect for antitumor research by supplying selenium. It is helpful to further study on the opportunity, advantages and disadvantages, methods and amount of supplemental seleni-um. (3) The specific distribution of selenium in patients with stomach carcinoma may cause the serum selenium level decline. (4) It should be noticed that the serum selenium level in some pa-tients is nearly normal, so it is necessary to pay more attention to "false negative" result in case the misdiagnosis happens.