| 内源性NO在应激状态下胃粘膜耐受性细胞保护中的作用 |
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| 引用本文： | 崔忠敏,李兆申,湛先保,许国铭.内源性NO在应激状态下胃粘膜耐受性细胞保护中的作用[J].第二军医大学学报,2000,21(1):7-9. |
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| 作者姓名： | 崔忠敏 李兆申 湛先保 许国铭 |
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| 作者单位： | 第二军医大学长海医院消化内科,上海,200433 |
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| 基金项目： | 军队医药卫生杰出中青年人才科研基金!资助项目（1996 卫科训字95 号） |
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| 摘 要： | 目的：探讨内源性ＮＯ在应激状态下胃粘膜耐受性细胞保护中的作用及其可能的机制。方法：采用重复浸水束缚应激（ＷＲＳ）制作动物模型,动态监测胃粘膜血流量（ＧＭＢＦ）,血浆及粘膜内ＮＯ含量的变化。结果：重复应激伴有ＧＭＢＦ的上升以及血浆,粘膜内ＮＯ含量的增高,且ＧＭＢＦ与血浆,粘膜内ＮＯ含量之间呈显著正相关,但它们占膜损伤之间呈显著负相关。
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| 关 键 词： | 应激 细胞保护 耐受性 一氧化氮 胃溃疡 |
| 文章编号： | 0258-879X(2000)01-0007-03 |
| 修稿时间： | 1999-09-15 |
Role of endogenous NO in gastric mucosal tolerant cytoprotection under stress |
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| CUI Zhong-Min,LI Zhao-Shen,ZHAN Xian-Bao,U Guo-Ming.Role of endogenous NO in gastric mucosal tolerant cytoprotection under stress[J].Academic Journal of Second Military Medical University,2000,21(1):7-9. |
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| Authors: | CUI Zhong-Min LI Zhao-Shen ZHAN Xian-Bao U Guo-Ming |
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| Institution: | CUI Zhong-Min
(Department of Gastroenterology, Changhai Hospital, Second Military Medical University,
Shanghai 200433, China)
LI Zhao-Shen
(Department of Gastroenterology, Changhai Hospital, Second Military Medical University,
Shanghai 200433, China)
ZHAN Xian-Bao
(Department of Gastroenterology, Changhai Hospital, Second Military Medical University,
Shanghai 200433, China)
U Guo-Ming
(Department of Gastroenterology, Changhai Hospital, Second Military Medical University,
Shanghai 200433, China) |
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| Abstract: | Objective: To study the role of endogenous NO in gastric mucosal tolerant cytoprotection under stress and the possible mechanism. Methods: SD rats were exposed to single or repeated WRS for 4 h every other day for up to 6 days, during which GMBF was measured using LDF 3 Flowmeter. NO levels in plasma and gastric mucosa were monitored by Griess reaction. Results: Gastric tolerant cytoprotection was accompanied by increased GMBF and NO levels in plasma and gastric mucosa. There was a positive proportion between GMBF and NO contents in plasma and gastric mucosa. Inversely, negative relationship was found between GMBF and NO levels in plasma and gastric mucosa and mucosal lesions. Conclusion: By regulating GMBF, endogenous NO might play an important role in the gastric mucosal tolerant cytoprotection under stress |
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| Keywords: | stress gastric mucosa cytoprotection tolerance nitric oxide |
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