高强度聚焦超声消融治疗子宫肌瘤的临床评价

目的:评价高强度聚焦超声(HIFU)精确定位消融治疗子宫肌瘤的临床效果。方法:对52例(87个肌瘤)子宫肌瘤患者,采用JC型聚焦超声肿瘤治疗系统在超声精确定位和实时监控下对靶肌瘤进行消融治疗。治疗1个月内以增强MRI观察靶肌瘤的消融率;治疗后6个月、12个月以平扫MRI评价靶肌瘤的缩小率,并随访患者月经量和血红蛋白的变化。结果:治疗1个月内靶肌瘤消融率为(83.2±13.6)%,治疗后6个月、12个月靶肌瘤体积明显缩小,与治疗前比较差异有显著性(P均<0.05),靶肌瘤缩小率分别为(56.04±23.65)%和(70.00±21.26)%。治疗后6个月、12个月患者月经周期缩短,月经量减少,血液血红蛋白(Hb)升高。治疗中及治疗后无严重并发症。结论:镇静镇痛下高强度聚焦超声精确定位消融治疗子宫肌瘤安全有效。

Clinical evaluation of high-intensity focused ultrasound ablation for hysteromyoma

Objective：To evaluate the clinical efficacy and safety of high-intensity focused ultrasound （ HIFU） by precise positioning for ablation of hyste-romyoma.Methods：By precise positioning and applying real-time monitoring system（JC-type）,52 patients with hysteromyoma （87 myomas） underwent ablation at the location of the focal field.One month after treatment,enhanced MRI was performed to determine the ablation rate for the target fibroids,and plain MRI was applied to evaluate the focal size reduction 6 months and 12 months after invention,respectively.The patients were also followed up for the changes of the menstruation and hemoglobin level.Results：The ablation rate of target fibroids was （83.2±13.6）% within one month after treatment.Six months and twelve months after treatment,the size of target fibroids was significantly reduced（56.04 ＆#177;23.65）%;（70.00 ±21.26）%,respectively], and the menstrual blood volume was reduced,whereas hemoglobin level was elevated.The difference was significant（all P 〈0.05）.No serious intra-or post-operative complications occurred.Conclusion：Under sedation analgesia,high-focused ultrasound by precise positioning for ablation of the hysteromyo-ma can be safe and efficacious.