| 多指标正交设计优选白术-白芍药对的提取工艺 |
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| 引用本文： | 张雯雯,徐志伟,曹岗. 多指标正交设计优选白术-白芍药对的提取工艺[J]. 浙江中医药大学学报, 2014, 0(5): 511-516 |
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| 作者姓名： | 张雯雯 徐志伟 曹岗 |
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| 作者单位： | 浙江中医药大学中药炮制技术研究中心,杭州311401 |
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| 基金项目： | 国家自然基金项目（81202918）;杭州市重大科技创新项目（20131813A23）;杭州市科技计划项目（20130533B68）;校级重点基金项目（2013ZZ12）. |
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| 摘 要： | [目的]优选出最佳的白术-白芍药对提取工艺.[方法]采用正交试验和多指标综合加权评分法,以白术中的白术内酯Ⅰ、白术内酯Ⅱ、白术内酯Ⅲ、苍术素和白芍中芍药苷、氧化芍药苷、芍药内酯苷、没食子酸8个指标性成分为考察指标,对影响白术-白芍药对提取工艺的因素进行考察.[结果]最佳的白术-白芍药对提取工艺是将白术、白芍药材（3∶2,w/w）均匀混合后加入10倍量的70％甲醇溶液,回流提取3次,每次1h.[结论]该提取工艺稳定可靠,可为白术-白芍药对的进一步研究提供参考.
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| 关 键 词： | 白术-白芍药对 正交试验 多指标 提取工艺 |
Extraction Process of Rhizoma Atractylodis Macrocephalae and Radix Paeoniae Alba Herbal Pair by Orthogonal Test of Multi-index |
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| Wenwen,Xu Zhiwei,Cao Gang. Extraction Process of Rhizoma Atractylodis Macrocephalae and Radix Paeoniae Alba Herbal Pair by Orthogonal Test of Multi-index[J]. Journal of Zhejiang University of Traditional Chinese Medicine, 2014, 0(5): 511-516 |
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| Authors: | Wenwen Xu Zhiwei Cao Gang |
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| Affiliation: | ( Research Center of TCM Processing Technology, Zhejiang Chinese Medical University, Hangzhou(311401), China) |
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| Abstract: | [Objective]To optimize the best extraction process of Rhizoma Atractylodis Macrocephalae and Radix Paeoniae Alba herbal pair.[Methods] Using orthogonal test and comprehensive weight of multi-index to investigate the extraction process,the contents of paeoniflorin,oxypaeoniflorin,albiflorin,gallic acid,Atractylenolide Ⅰ,atractylenolide Ⅱ,atractylenolide Ⅲ,atisine chloride atractydin were regarded as the indexes.[Results] The optimum technical condition was as follows：extract 3 times with 10 times amount of 70% methanol and 1 hour for each time.[Conclusion] The optimized extraction process is stable and reliable.It can provide a reference for mass production. |
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| Keywords: | Rhizoma Atractylodis Macrocephalae and Radix Paeoniae Alba herbal pair orthogonal test multi-index extraction process |
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