Gallium scintigraphy in Hansen's disease |
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Authors: | Francisco José H. N. Braga Elaine B. Araújo Edwaldo E. Camargo Leontina C. M. Tedesco-Marchesi Maria Cecilia M. Rivitti Hateme Bouladour Pierre Galle |
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Affiliation: | (1) Service de Biophysique de Médecine Nucleaire, Hôpital Henri Mondor, Assistance Publique, Hôpitaux de Paris, Paris, France;(2) Serviço de Dermatologia, São Paulo University School of Medicine, São Paulo, Brazil;(3) Centro de Medicina Nuclear, São Paulo University School of Medicine, São Paulo, Brazil;(4) Serviço de Medicina Nuclear do Hospital das Clinicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo, Ribeirão Preto, 14048 SP, Brazil |
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Abstract: | Gallium 67 imaging was used in 12 patients with documented Hansen's disease undergoing treatment or not, in an attempt to determine the pattern of the disease. Diagnosis was confirmed by histopathology in all patients. The Mitsuda reaction was seen in all patients. Specific nuclear studies were performed when needed to evaluate particular organs better. Gallium 67 images show homogeneous, diffuse and moderate accumulation over the entire skin surface (except for the face) of untreated patients with multibacillary disease. The facial skin in these cases presented homogeneous, diffuse but very marked uptake of gallium. Internal organ involvement was variable. There was a very good correlation among clinical, scintigraphic, immunological and histopathological data. The pattern of the body skin (skin outlining) and facial skin (beard distribution) may be distinct for untreated patients with multibacillary leprosy. |
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Keywords: | Leprosy Hansen's disease Gallium 67 Scintigraphy |
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