Pertussis toxin induces fatty liver, hyperlipemia and ketosis in hamsters |
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| Authors: | J A García-Sáinz J Juárez-Ayala V E Valles |
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| Affiliation: | 1. Departamento de Bioenergética, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Apartado Postal 70-248; 04510 México, D.F.;2. Departamento de Diabetes y Metabolismo de Lípidos, Instituto Nacional de la Nutrición “Salvador Zubirán” México 14000, D.F.;1. Department of Hematology, Institute of Hematology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China;2. Department of Medical Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China;3. Gastric Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China;4. Key Laboratory of Drug Targeting and Drug Delivery Systems, Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu 610041, China;1. Department of Agriculture and Forestry Engineering, Food Technology, College of Agricultural and Forestry Engineering, University of Valladolid, Av. Madrid, 44, 34004 Palencia, Spain;2. Laboratory of Food Chemistry & Biochemistry, Department of Food Science and Technology, School of Agriculture, Aristotle University of Thessaloniki, Thessaloniki 541 24, Greece;1. Department of Health Sciences, Division of Obstetrics and Gynecology, Careggi Hospital, Florence, Italy;2. Department of Health Sciences, Clinical Pharmacology and Oncology Section, University of Florence, Italy;3. Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence, Italy;1. Nomis Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, 10010 N. Torrey Pines Road, La Jolla, CA 92037, USA;2. Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92037, USA;3. The Razavi Newman Integrative Genomics and Bioinformatics Core Facility of the Salk Institute for Biological Studies, 10010 N. Torrey Pines Road, La Jolla, CA 92037, USA;4. Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 N. Torrey Pines Road, La Jolla, CA 92037, USA;1. Imperial College Parturition Research Group, Institute of Reproductive and Developmental Biology, Imperial College London, London, United Kingdom;2. Academic Department of Obstetrics and Gynaecology, Chelsea and Westminster Hospital, London, United Kingdom;3. Gene Transfer Technology Group, Institute for Women''s Health, University College London, London, United Kingdom;5. UCL Centre for Perinatal Brain Protection & Repair, Institute for Women''s Health, University College London, London, United Kingdom;4. Antiviral Gene Therapy Research Unit, Faculty of Health Sciences, University of the Witswatersrand, Johannesburg, South Africa;6. Department of Clinical Sciences, Perinatal Center, University of Gothenburg, Gothenburg, Sweden;7. Division of Imaging Sciences and Biomedical Engineering, Centre for the Developing Brain, King''s College London, King''s Health Partners, St. Thomas'' Hospital, London, United Kingdom |
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| Abstract: | Pertussis toxin markedly affects lipid metabolism in hamsters. The toxin induces a time-dependent and dose-dependent accumulation of triacylglycerols in the liver (fatty liver) and moderate increases in cholesterol and phospholipids. These toxin produced dramatic increases in the amounts of triacylglycerols, free fatty acids and ketone bodies in the serum and small increases in cholesterol and phospholipids. It is suggested that an enhanced and unregulated lipolysis may play a key role in the induction of these alterations by the toxin. |
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