子宫肌瘤不同术式对内分泌影响的临床研究

目的研究子宫肌瘤不同的手术方式对患者内分泌功能的影响作用。方法 107例子宫肌瘤患者根据不同术式分为观察组1(行子宫肌瘤剥除术)22例、观察组2(行子宫全切或次全切,保留双附件)67例,观察组3(行子宫全切,双附件切除)18例,比较各组研究对象手术前后性激素水平变化。结果观察组1术前、术后8周及术后24周性激素FSH、LH、E2均无统计学差异(P>0.05);观察组2术后8周FSH、LH、E2与术前无统计学差异(P>0.05);术后24周FSH、LH、E2与术前有统计学差异(P<0.05)。FSH、LH出现升高,E2出现下降;观察组3术后8周FSH、LH、E2与术前有统计学差异(P<0.05);术后24周FSH、LH、E2与术前统计学差异有显著性(P<0.01)。FSH、LH出现升高,E2出现下降;三组术后一年内出现围绝经症状比例分别为9.1%、23.9%、83.3%,存在统计学差异(P<0.05),以观察组3最高。结论不同术式对子宫肌瘤患者内分泌功能影响不同,临床应根据患者选择合适手术方式。

Clinical Study on the Effects of Different Surgical Uterine Fibroids on Endocrine

Objective To study different surgical methods influence of endocrine function in patients with uterine fibroids. Methods 107 cases of uterine fibroids patients according to different operation was divided into the observation group 1 （ uterine fibroids cysteotomy ） in 22 cases, the observation group 2 （ row hysterectomy or subtotal, retain double accessories ） in 67 cases, the observation group 3 （ line of hysterectomy, bilateral salpingo-oophorectomy ） in 18 cases, variability hormone levels before and after operation were compared among the three groups. Result Sex hormones FSH, LH, Fa observed in group 1 preoperative and postoperative 8 weeks and 24 weeks after the operation there was no significant difference （P〉O.05）; In the observation group 2, FSH, LH, F~ 8 weeks after surgery and preoperative no statistical difference （P〉0.05）; FSH, LH, E2 24 weeks after surgery and preoperative had significant difference （P〈0.05）. FSH, LH increased, E2 decreased; In the observation group 3, FSH, LH, Fa 8 weeks after surgery and preoperative had significant difference （P〈0.05）; FSH, LH, E2 after 24 weeks compared with those before operation, had significant statistical differences （P〈0.01）. FSH, LH increased, Fa decreased; the three group after a year of perimenopausal symptoms was respectively 9.1%, 23.9%, 83.3%, there was sigrfificant difference （P〈0.05）, to observe the 3 highest.eonelusion Different surgical endocrine function in patients with uterine fibroids affect different clinical surgery should be based on the patient to choose the right way.