| 月桂氮酮对无环鸟苷霜体外透皮吸收作用的影响 |
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| 引用本文： | 陈钧,何凤慈.月桂氮酮对无环鸟苷霜体外透皮吸收作用的影响[J].药学实践杂志,1998(5). |
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| 作者姓名： | 陈钧 何凤慈 |
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| 作者单位： | 第三军医大学野战外科研究所大坪医院药剂科!重庆，400042，第三军医大学野战外科研究所大坪医院药剂科!重庆，400042 |
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| 摘 要： | 考察不同浓度月桂氮酮对无环鸟苷霜的透皮促渗作用，进行合理的处方筛选。以离休兔皮为渗透屏障，采用改良Franz扩散池，研究不同浓度氮酮对无环鸟昔的透皮促渗作用。无环鸟苷霜的透皮吸收为零级动力学过程，氮酮对无环鸟苷的透皮促渗作用无浓度依赖性，经试验测得2％氮酮对无环鸟苷的促渗作用最强。
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| 关 键 词： | 月桂氮酮 无环鸟苷 透皮吸收 |
Effect of azone on the permeability of acyclorior cream thought rabbit skin in vitro |
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| Chen Jun,He Fengci.Effect of azone on the permeability of acyclorior cream thought rabbit skin in vitro[J].The Journal of Pharmaceutical Practice,1998(5). |
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| Authors: | Chen Jun He Fengci |
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| Abstract: | To investigate the effect of the different concertration of azone on the acyclovir(ACV)cream, in order to optimize the formulation. We determined the transdermal amount of the ACV and steady-state-rate of penetration in vitro, using the improved-Frenz cell and excised rabbit skin as transdermal barrier in permeation test. The result indicated transdermal absorption of ACV followed zeroorder kinetics, and the penetration enhance effect of Azone was independent with the concertration. The ACV cream containing 2% Azone showed remarkable effect to enhance the transdermal delivery amount of ACV. |
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| Keywords: | acyclovrir transdermal delivery |
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