新生儿高胆红素血症对婴幼儿智能发育的影响

目的：探讨新生儿高胆红素血症对婴幼儿智力发育的远期影响。方法选择66例高胆红素血症患儿作为观察组，另选取同期60例健康新生儿纳入对照组，对2组新生儿的出生资料、临床诊疗资料及随访记录进行回顾性分析。结果观察组新生儿神经行为评分（NBNA）明显低于对照组（P〈0.01）；随访期间在大运动、精细动作、适应能力、语言和社会交往方面比较，在12个月、24个月时的发育商评分均显著低于对照组（P〈0.01）。结论高胆红素血症对新生儿神经行为能力和婴幼儿智能发育均有一定影响，因此在临床中应积极处理新生儿高胆红素血症，及早进行治疗干预，防治高胆红素血症对婴幼儿智能发育的危害。

Remote effect of neonatal hyperbilirubinemia on mental development of infants

Objective To observe the effect of Neonatal hyperbilirubinemia on mental development of infants. Methods 66 children with hyperbilirubinemia treated in our hospital from January 2009 to January 2011 were selected into the observation group. While during the period 60 healthy newborns in our hospital were selected into the control group. The birth data, clinical diagnosis and treatment information and follow-up note of the newborns in the 2 groups were analyzed retrospectively. Results Children of neonatal hyperbilirubinemia were worse in neural behavior than the normal babies. The control group was better evidently than the observation group during the follow-up period （P〈0.05）. For the intelligence score comparison of gross motor, fine motor, adaptation ability, language ability and social ability , the observation group were lower obviously than the control group in 12 and 24 months （P〈0.05）. Conclusion Children of neonatal hyperbilirubinemia were worse in neural behavior and intelligence during the follow -up period after recovery. So we should strengthen on the monitor of neonatal serum bilirubin in the clinical, and make therapeutic intervention early to reduce the incidence of hyperbilirubinemia.