Virus-like particles in cultured human glioma |
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Authors: | Eiichi Tani Juji Takeuchi Toshio Ametani |
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Affiliation: | (1) Laboratory Division, Department of Neurosurgery, Kyoto University Medical School, Shogoin, Kyoto, Japan |
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Abstract: | Summary Mature type C virus-like particles were found in the extracellular site of human glioblastoma multiforme cells cultured in bottles for 30 days after inoculation. They were target-like in feature and about 100–110 m in diameter, surrounded by a limiting membrane. A homogeneously dense core, around 60–70 m in diameter, was located in the center of the particle. Evidence for the presence of other forms of virus-like particles or for the budding at the cell membrane of virus-like particles was not yet found.
Zusammenfassung Reife, virusähnliche Partikel vom Typ C fanden sich in einem menschlichen Glioblastoma multiforme 30 Tage nach Inoculation auf Flaschen-Zellkulturen. Die Partikel waren ringförmig mit einem Durchmesser von 100–110 m und von einer Membran messer. Hinweise auf das Vorliegen anderer Formen virusartiger Partikel oder auf eine Entstehung virusähnlicher Partikel an der Zellmembran fanden sich noch nicht. |
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Keywords: | Human Glioblastoma Multiforme Cell Culture Type C Virus-like Particle |
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