| 巴丹、易卫杀在大鼠胃匀浆中生物转化的研究 |
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| 引用本文： | 赵云峰,王绪卿,陈惠京,朱家琦. 巴丹、易卫杀在大鼠胃匀浆中生物转化的研究[J]. 卫生研究, 1995, 0(6) |
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| 作者姓名： | 赵云峰 王绪卿 陈惠京 朱家琦 |
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| 作者单位： | 中国预防医学科学院营养与食品卫生研究所 |
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| 基金项目： | 1992～1994年国家自然科学基金 |
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| 摘 要： | 建立了胃匀浆中巴丹、易卫杀的ＧＣ－ＦＰＤ测定方法，并用此方法观察了巴丹、易卫杀在大鼠胃匀浆中的转化。添加巴丹的胃匀浆样品，经Ｎａ２Ｓ溶液转化生成沙蚕毒素，其回收率为１０３．１％［ｎ＝４，ＲＳＤ（％）＝０．７３］；添加易卫杀的胃匀浆样品，其回收率为１００．５％［ｎ＝４，ＲＳＤ（％）＝０．５４］。在大鼠胃匀浆中分别添加巴丹、易卫杀后，１ｍｉｎ时，分别有４９．７％和２８．８％的巴丹、易卫杀转化成沙蚕毒素；至１０ｍｉｎ时，加入的巴丹及易卫杀大部分转化生成沙蚕毒素。结果显示，巴丹和易卫杀在大鼠体内极易转化成沙蚕毒素。
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| 关 键 词： | 巴丹，易卫杀，沙蚕毒素 |
Research on metabolic transformation of cartap and evisect in stomach homogenate of rats in vitro |
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| Zhao Yunfeng,Wang Xuqing,Chen Huijing,Zhu Jiaqi. Research on metabolic transformation of cartap and evisect in stomach homogenate of rats in vitro[J]. Journal of hygiene research, 1995, 0(6) |
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| Authors: | Zhao Yunfeng Wang Xuqing Chen Huijing Zhu Jiaqi |
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| Abstract: | GC-FPD methods were established to observe cartap and evisect biotransformation in the stomach homogenate of rats.The recoveries of cartap and evisect were 103.1%(n=4,RSD=0.73%)and 100.5%(n =4,RSD=0, 54%),respectively. cartap of evisect were added in stomach homogenate of rats respectively.After 1min,49.1%of Cartap and 28.8%of Evisect were converted to Nereistoxin. After 10min,most of them were metabolized to Nereistoxin. It is concluded that these pesticides are transformed to Nereistoxin quite rapidly in rats. |
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| Keywords: | cartap evisect nereistoxin |
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