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目的评价不同浓度平阳霉素局部注射治疗口腔颌面部淋巴管畸形的临床疗效。方法回顾分析2006年1月至2013月5月在中国医科大学附属口腔医院口腔颌面外科采用平阳霉素局部注射治疗的82例淋巴管畸形患者的临床资料。对不同类型、同一类型不同大小的淋巴管畸形采用不同浓度的平阳霉素治疗,具体如下：微囊型淋巴管畸形为8 mg/8 mL;病损直径〈5 cm的大囊型及混合型淋巴管畸形为8 mg/5 mL;病损直径〉5 cm的大囊型淋巴管畸形为8 mg/3 mL。随访时间为6个月至3年。结果微囊型淋巴管畸形治愈率为43.3%;病损直径〈5 cm的大囊型淋巴管畸形治愈率为93.3%;病损直径〉5 cm的大囊型淋巴管畸形治愈率为88.9%;混合型淋巴管畸形的治愈率为60.0%。所有患者术后均出现局部肿胀、疼痛,出现全身发热4例,出现局部溃疡1例,均未见肺纤维化及严重不良反应发生。结论对不同类型、同一类型不同大小的淋巴管畸形采用适宜浓度的平阳霉素进行治疗,不仅可以提高疗效、缩短疗程,而且可以减少不必要的并发症发生,治疗相对安全。

The efficacy of treatment of intralesional injection of pingyangmycin with different concentrations for lymphatic malformations in oral and maxillofacial region

Objective To investigate the therapeutic effects of intralesional injection of different concentrations of pingyangmycin for lymphatic malformations in oral and maxillofacial region. Methods From January 2006 to May 2013, eighty-two patients with lymphatic malformations of oral and maxillofaeial region who had been treated with intralesional injection of different concentrations of pingyangmycin were retrospectively analyzed. For microcystic lymphatic malformation, the concentration of pingyangmycin was 8mg/8mL; for macrocystic lymphatic malformation （less than 5cm） and mixed lymphatic malformation, the concentration of the drug was 8mg/SmL, while 8mg/3mL for macrocystic lymphatic malformation（more than 5cm）. The follow-up period was 6 months to 3 years after the last treatment. Results The clinical cure rate of microcystic lymphatic malformation, macrocystic lymphatic malformation （less than 5cm）, macrocystic lymphatic malformation （more than 5era）, and mixed lymphatic malformation was 43.3%, 93.3%, 88.9%, and 60% respectively. Local swelling happened in all patients and four patients had fever as well as ulceration found in one patient. There were no pulmonary fibrosis, or other serious complications. Conclusion Using appropriate concentration of pingyangmycin for lymphatic malformations in different types and different sizes of the same type can not only improve the efficacy and shorten the course of treatment but also reduce the incidence of complications.