索拉非尼联合放射治疗肝癌研究进展 |
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引用本文: | 郑青平[综述] 李旌[审校]. 索拉非尼联合放射治疗肝癌研究进展[J]. 中国医学文摘:老年医学, 2012, 0(9): 883-887 |
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作者姓名: | 郑青平[综述] 李旌[审校] |
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作者单位: | 柳州市人民医院肿瘤放疗科,广西545001 |
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基金项目: | 基金项目:广西柳州市科学研究与技术开发计划项目(编号:2008031425) |
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摘 要: | 索拉非尼是多靶点激酶抑制剂,通过抗增殖和抗血管形成作用抑制肿瘤细胞生长和血管形成,其作用机制是靶向抑制丝裂原活化蛋白激酶(Ras/Raf/MAPK)、血管内皮生长因子/血管内皮生长因子受体(VEGF/VEGFR)和核因子KB(NF-KB)等信号传导通路,而这些信号通路在放射时被激活,在肿瘤发生发展过程中起着重要的作用。研究显示,索拉非尼联合放射治疗原发性肝癌有协同效应,但联合方案的基础和临床研究有待进一步探索。
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关 键 词: | 索拉非尼 放射疗法 肝细胞癌 |
Research progress on sorafenib combined with radiation in treatment of hepatocellular carcinoma |
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Affiliation: | ZHENG Qing-ping, LI .ling. Department of Radiation Oneology, the People's Hospital of Liuzhou, Cuangxi 545001, China |
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Abstract: | Sorafenib is a multikinase inhibitor that acts by inhibiting tumor growth and disrupting tumor mi- erovaseulature through antiproliferative and anti-angiogenie effects. It exerts these effects via inhibition of multiple tar- gets including Ras/Raf/MAPK, VEGF/VEGFR and NF-KB signal pathways, which can be induced by radiation. Sorafenib combined with radiation in hepatoeellular carcinoma treatment has been explored and shown synergistic re- sults. The basic and clinical studies on the effects and roechanisms of the combining modality should be further inves- tigated. |
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Keywords: | Sorafenib Radiation Hepatocellular carcinoma |
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