| 芒果甙抗肿瘤作用机制研究进展 |
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| 引用本文： | 刘晓春[综述] 焦伟[审校]. 芒果甙抗肿瘤作用机制研究进展[J]. 中国医学文摘:老年医学, 2012, 0(10): 977-981 |
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| 作者姓名： | 刘晓春[综述] 焦伟[审校] |
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| 作者单位： | 广西壮族自治区人民医院临检中心,南宁530021 |
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| 基金项目： | 广西自然科学基金资助项目（编号：桂科青0447018） |
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| 摘 要： | 芒果甙是一种黄酮类化合物，具有多种生理和药理作用，近期的研究报道芒果甙具有抗肿瘤作用。芒果甙抗肿瘤作用主要包括抑制肿瘤细胞增殖生长、阻断细胞周期、诱导细胞凋亡、抑制NF-κB信号途径激活、影响E-cad介导的细胞黏附及信号转导、干预线粒体通透性转换及与化疗药物发挥联合作用等。
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| 关 键 词： | 芒果甙 抗肿瘤机制 |
Research progress on mangiferin anti-tumor mechanism |
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| Affiliation: | LIU Xiao-chun, JIAO Wei. Guangxi Center for Clinical Laboratory,the People＇s Hospital of Guangxi Zhuang Autonomous Region ,Nanning 530021, China |
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| Abstract: | Mangiferin is a flavonoid compound and has a variety of physiological and pharmacological effects. Recent studies have reported that mangiferin has anti-tumor effect. Mangiferin anti-tumor mechanism includes inhibi- tion of tumor cell proliferation and growth, blocking the cell cycle, induction of apoptosis, inhibition of NF-κB signa- ling pathway activation, interference in E-cadherin-mediated cell adhesion and signal transduction, intervention of mi- tochondrial permeability transition and the combined effects of chemotherapy drugs. |
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| Keywords: | Mangiferin Anti-tumor mechanism |
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