癌胚抗原、糖链抗原72-4和胃蛋白酶原联合检测评价胃癌的诊断价值

目的探讨血清癌胚抗原(CEA)、糖链抗原72-4(CA72-4)和胃蛋白酶原(PG)在胃癌诊断中的价值。方法分别检测CEA、CA72-4、PGⅠ、PGⅡ和PGⅠ/Ⅱ在96名正常对照组、37例胃增生患者和107例胃癌患者的血清含量。结果当CA72-4、CEA、PGⅠ、PGⅡ和PGⅠ/Ⅱ单独评价胃增生和胃癌的诊断价值,诊断能力最好的是CA72-4,其敏感性和特异性分别为72.00%和59.50%。利用二元Logistic回归评价CEA和CA72-4联合诊断评价胃增生和胃癌的曲线下面积为0.715,其敏感性和特异性分别为70.10%和67.60%,与指标单独检测敏感性和特异性都有提高。多层感知器神经网络分析用来分析CEA和CA72-4联合诊断时,曲线下面积为0.711。结论本研究证明联合检测的诊断价值优于单独检测,为临床胃癌诊断提供一定的理论指导。

Evaluation on the diagnostic value of CEA, CA72-4 and pepsinogen combined determination for gastriccancer

Objective To investigate the diagnostic value of serum carcinoembryonic antigen （CEA）, carbohydrate antigen 72-4 （CA72-4） and pepsinogen （PG） combined determination for gastric cancer. Methods Serum CEA, CA72-4, PG Ⅰ , PG Ⅱ and PG Ⅰ / Ⅱ were detected in 96 healthy controls, 37 gastric hyperplasia patients and 107 gastric cancer patients. Results When the CA72-4, CEA, PGⅠ , PG Ⅱand PG Ⅰ / Ⅱ were used to diagnose gastric hyperplasia and gastric cancer individually, CA72-4 had the best diagnostic capability. Its sensitivity and specificity were 72.00% and 59.50%. Binary logistic regression was used to evaluate the diagnostic value of combining CEA and CA72-4 to diagnose the gastric hyperplasia and gastric cancer. The area under the curve was 0. 715, and the sensitivity and specificity were 70.10% and 67.60%. Compared to the sensitivity and specificity of each marker, the sensitivity and specificity of combined determination with 3 markers were better. Muhilayer perceptron neural network analysis was also used to analyze the diagnostic value of CEA and CA72-4 combined determination. The area under the curve was 0.711. Conclusions The diagnostic value of the combined determination is superior, and it also provides reference for the clinical diagnosis of gastric cancer.