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| 尿液中足细胞标志蛋白和微量白蛋白对糖尿病肾病的诊断性能评价 | |
| 引用本文： | 叶俊,罗红,李坤,马威. 尿液中足细胞标志蛋白和微量白蛋白对糖尿病肾病的诊断性能评价[J]. 检验医学, 2012, 27(7): 568-570 |
| 作者姓名： | 叶俊 罗红 李坤 马威 |
| 作者单位： | 1. 武汉市第四医院检验科,湖北武汉,430030 2. 武汉市第一医院检验科,湖北武汉,430022 3. 武汉市中西医结合医院中心实验室,湖北武汉,430022 |
| 摘 要： | 目的探讨应用受试者工作特征(ROC)曲线评价尿液中足细胞标志蛋白(PCX)和微量白蛋白(mAlb)联合检测对糖尿病肾病(DN)早期诊断的价值。方法用ROC曲线对35例DN和47例未见肾脏病变的糖尿病(DM)患者尿液中PCX、mAlb、PCX与mAlb联合检测(PCX+mAlb)的结果进行分析评价。结果 DN组尿液PCX、mAlb水平均高于DM组(P<0.01);DN患者的PCX、mAlb、PCX+mAlb的ROC曲线下面积分别为0.872、0.921、0.973;建立的临床诊断个体判别公式为预测概率值(P)=1/[1+e-(-5.030+0.067mAlb+0.097PCX)],P≥0.565判为阳性(诊断为DN)。结论通过ROC曲线评价,PCX+mAlb联合检测诊断DN优于PCX或mAlb单项检测。 |
| 关 键 词： | 足细胞标志蛋白 微量白蛋白 糖尿病肾病 受试者工作特征曲线 |
Performance of urine podocalyxin and microalbuminuria in the diagnosis of diabetic nephropathy |
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| YE Jun , LUO Hong , LI Kun , MA Wei. Performance of urine podocalyxin and microalbuminuria in the diagnosis of diabetic nephropathy[J]. Laboratory Medicine, 2012, 27(7): 568-570 | |
| Authors: | YE Jun LUO Hong LI Kun MA Wei |
| Affiliation: | 3. ( 1. Department of Clinical Laboratory, the Forth Hospital in Wuhan, Hubei Wuhan 430030, China ; 2. Department of Clinical Laboratory, the First Hospital in Wuhan, Hubei Wuhan 430022, China; 3. Central Laboratory, the Hospital of Integrated Traditional and Western Medicine in Wuhan, Hubei Wuhan 430022, China) |
| Abstract: | Objective To study the significance of podocalyxin （PCX）, microalbuminuria （mAlb） and the combined detection of urine PCX and mAlb in the early diagnosis of diabetic nephropathy （DN） by receiver operating characteristic （ROC） curve. Methods The detection results of PCX,mAlb, PCX ＋ mAlb from 35 DN patients and 47 diabetes mellitus（DM） patients were evaluated by ROC curve. Results PCX and mAlb of DN group were significantly higher than those of DM group （P 〈0.01 ）. The areas under ROC curve of PCX,mAlb and PCX ＋ mAlb in DN patients were 0. 872,0. 921 and 0. 973 respectively. The singje discrimination equation was predictive probability value （P） = 1/ [ 1 ＋ e-（＇5030＋O＇067mAlb＋0＂097PcX） ]. When P〉~0.565 ,it was positive and diagnosed as DN. Conclusions By the evaluation of urine ROC curve, the combined detection of urine PCX and mAlb is better than PCX or mAlb individual detection for the diagnosis of DN. |
| Keywords: | Podocalyxin Microalbuminuria Diabetic nephropahty Receiver operating characteristic curve |
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