| 多柔比星前体脂质体制备工艺筛选及质量考察 |
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| 引用本文： | 郑稳生,王璐璐,张宇佳,方夏琴. 多柔比星前体脂质体制备工艺筛选及质量考察[J]. 中国药师, 2012, 15(8): 1130-1134 |
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| 作者姓名： | 郑稳生 王璐璐 张宇佳 方夏琴 |
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| 作者单位： | 中国医学科学院药物研究所,药物传输技术及新型制剂北京市重点实验室,北京,100050 |
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| 摘 要： | 目的:筛选多柔比星前体脂质体制备工艺及条件,并对其性状、包封率进行考察评价.方法:运用均匀设计法筛选制备条件,葡聚糖凝胶层析法、紫外分光光度法测定包封率.结果:按照最佳处方所制得多柔比星前体脂质体粒径分布均匀,形态良好,包封率可达80%.结论:按照均匀设计法制备的多柔比星前体脂质体性状优良,检测方法可靠,制备方法简单可行,质量可控,具有广阔的应用前景.
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| 关 键 词： | 多柔比星 前体脂质体 制备工艺 质量考察 |
| 收稿时间： | 2012-03-16 |
| 修稿时间： | 2012-05-22 |
Preparation and Quality Evaluation of Doxorubicin loaded Proliposomes |
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| Lulu,Zhang Yuji,Fang Xiaqin,Lulu,Zhang Yuji,Fang Xiaqin,Lulu,Zhang Yuji,Fang Xiaqin and Lulu,Zhang Yuji,Fang Xiaqin. Preparation and Quality Evaluation of Doxorubicin loaded Proliposomes[J]. China Pharmacist, 2012, 15(8): 1130-1134 |
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| Authors: | Lulu Zhang Yuji Fang Xiaqin Lulu Zhang Yuji Fang Xiaqin Lulu Zhang Yuji Fang Xiaqin Lulu Zhang Yuji Fang Xiaqin |
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| Affiliation: | ( Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing Key Laboratory of Drug Delivery Technology and New Formulations, Beijing 100050, China) |
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| Abstract: | Objective： To screen the preparation process and conditions of doxorubicin-loaded proliposomes, and evaluate the qualities. Method： Uniform design was applied to screen the optimal preparation conditions, and Sephadex chromatography and UV spectrophotometry were used to determine the entrapment efficiency. Result： Doxorubiein-loaded proliposomes prepared by the result of the uniform design showed narrow size distribution and good shape with the entrapment efficiency up to 80%. Conclusion： The prepared doxorubiein-loaded proliposomes exhibit reliable determination method, feasible preparation technology and controllable quality, suggesting broad application prospects. |
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| Keywords: | Doxorubicin Proliposomes Preparation Quality evaluation |
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