|
|||||
|
|
| 槟榔壳总酚类提取物抗抑郁作用研究 | |
| 引用本文： | 何嘉泳,陈杰桃,辛志添,黄保,陈晓盈,何细新,江仁望.槟榔壳总酚类提取物抗抑郁作用研究[J].中国药师,2012,15(8):1076-1078. |
| 作者姓名： | 何嘉泳 陈杰桃 辛志添 黄保 陈晓盈 何细新 江仁望 |
| 作者单位： | 1. 广州中医药大学中药学院,广州,510006 2. 广州中医药大学中药学院,广州,510006;暨南大学中药及天然药物研究所 3. 暨南大学中药及天然药物研究所 |
| 基金项目： | 2011广东省大学生创新实验项目（编号：1057211031）; 国家教育部回国人员科研启动基金（编号：教外司留[2008]890号）; 广东省高等学校高层次人才项目（编号：2010[79]） |
| 摘 要： | 目的:探讨槟榔壳总酚类提取物对抑郁模型小鼠的抗抑郁作用。方法:采用小鼠悬尾、强迫游泳等抑郁模型,以小鼠行为绝望的不动时间作为指标,考察槟榔壳总酚类抗抑郁活性。结果:槟榔壳总酚类320,160 mg.kg-1剂量组均能显著减少小鼠悬尾和强迫游泳的不动时间。结论:槟榔壳总酚类可以改善小鼠的绝望行为,具有明显的抗抑郁作用。 |
| 关 键 词： | 槟榔壳 总酚类 抗抑郁 悬尾实验 强迫游泳实验 |
| 收稿时间： | 2012/3/27 0:00:00 |
| 修稿时间： | 5/7/2012 12:00:00 AM |
Antidepressant Activity of Total Phenolic Extracts from the Shell of Areca Catechu |
|
| He Jiayong,Chen Jietao,Xin Zhitian,Huang Bao,Chen Xiaoying,He Xixin and Jiang Renwang.Antidepressant Activity of Total Phenolic Extracts from the Shell of Areca Catechu[J].China Pharmacist,2012,15(8):1076-1078. | |
| Authors: | He Jiayong Chen Jietao Xin Zhitian Huang Bao Chen Xiaoying He Xixin and Jiang Renwang |
| Institution: | 1. College of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou 510006, China; 2. Institute of Traditional Chinese Medicine ＆ Natural Products, Jinan University) |
| Abstract: | Objective： To investigate the antidepressant effects of total phenolic extracts trom the shell ot Areca catechu. Method ： The tail suspending test （TST） and forced swimming test（FST） were carried out to determine the antidepressant activity of total phe- nolic extracts from the shell of Areca catechu in mice with the immobility time as the index. Result： The total phenolic extracts at the dosage of 320 and 160 mg ~ kg-1 could significantly shorten the mouse immobility time in TST and FST. Conclusion： The total phenolic extracts from the shell of Areca catechu with antidepressant activity can obviously improve the symptoms of the depressive mice. |
| Keywords: | Areca catechu Total phenolic extracts Antidepressant Tail suspending test Forced swimming test |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |
| 点击此处可从《中国药师》浏览原始摘要信息 | |
| 点击此处可从《中国药师》下载免费的PDF全文 | |