| 卤族类吸入麻醉药心肌保护机制的研究进展 |
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| 引用本文： | 方衍锋,张锦英,刘国利. 卤族类吸入麻醉药心肌保护机制的研究进展[J]. 心血管病学进展, 2009, 30(6) |
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| 作者姓名： | 方衍锋 张锦英 刘国利 |
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| 作者单位： | 辽宁医学院附属第一医院麻醉科,辽宁,锦州,121001 |
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| 基金项目： | 辽宁省教育厅科研基金项目 |
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| 摘 要： | 心肌缺血的药物防治一直是研究的重点之一。大量的基础研究证实吸入麻醉药对缺血心肌有保护作用,在一些临床试验中也得到初步证实,其保护机制复杂,尚未完全阐明,现就其在ATP敏感性钾通道开放、Ca2+超载、氧自由基、细胞因子,一氧化氮等方面的研究进展作一综述。
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| 关 键 词： | 吸入麻醉药 心肌保护 机制 |
Progress of Mechanism of Myocardial Protection by Inhaled Anesthetics |
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| FANG Yan-feng,ZHANG Jin-ying,LIU Guo-li. Progress of Mechanism of Myocardial Protection by Inhaled Anesthetics[J]. Advances in Cardiovascular Diseases, 2009, 30(6) |
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| Authors: | FANG Yan-feng ZHANG Jin-ying LIU Guo-li |
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| Affiliation: | FANG Yan-feng; ZHANG Jin-ying; LIU Guo-li(Department of Anesthesiology; The First Affiliated Hospital of Liaoning Medical College; Jinzhou 121001; China); |
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| Abstract: | The protection of ischemic myocardium by drugs has long been a focus of study. It has been proven through numerous that inhaled anesthetics-induced protection against ischemic myocardium exists. This has also tentatively been confirmed in clinical trials. However, the mechanism of protection is complicated and has not yet been completely elucidated. Progress made in the research of inhaled anesthetics in the opening of ATP-sensitive potassium channels, Ca~(2+) overload, oxygen free radicals, cytokines and NO is summarized in this review. |
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| Keywords: | inhaled anesthetics myocardial preservation mechanism |
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