| Photodynamic Therapy for Age-related Macular Degeneration |
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| 作者姓名： | Chenjin Jin Jian Ge Shaobo Zhou Huiyi Chen Xiaojing Zhong Ruzhang Jiang Lingyan Chen Lirong ChenZhongshan Ophthalmic Center Sun Yat-sen University Guangzhou China |
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| 作者单位： | Chenjin Jin，Jian Ge，Shaobo Zhou，Huiyi Chen，Xiaojing Zhong，Ruzhang Jiang，Lingyan Chen，Lirong ChenZhongshan Ophthalmic Center，Sun Yat-sen University，Guangzhou 510060，China |
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| 摘 要： | PrefaceAge鄄relatedmaculardegeneration(AMD)isanimportantchallengetoophthalmologistsinthe21stcentury.Worldwide,itisthemostcom鄄moncauseoflegalblindnessamongindividualsolderthan60years1].ItisknownthatseverevisionlossinmajorityofpatientswithAMDisduotochoroidalneovascularization(CNV).Laserphot鄄ocoagulationistheonlylong鄄termtreatmentoptionforneovascularAMDandisindicatedforextrafovealorjuxtafoveallesion.Inthesecaseslasertreatmentcancauseirreversibledamagetotheretinalpigmentepitheliumandsens…
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| 关 键 词： | 光力学 治疗 黄斑变性 AMD |
Photodynamic Therapy for Age-related Macular Degeneration |
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| Chenjin Jin,Jian Ge,Shaobo Zhou,Huiyi Chen,Xiaojing Zhong,Ruzhang Jiang,Lingyan Chen,Lirong ChenZhongshan Ophthalmic Center,Sun Yat-sen University,Guangzhou ,China.Photodynamic Therapy for Age-related Macular Degeneration[J].Eye Science,2004,20(3):158-162. |
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| Authors: | Chenjin Jin Jian Ge Shaobo Zhou Huiyi Chen Xiaojing Zhong Ruzhang Jiang Lingyan Chen Lirong Chen |
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| Institution: | Zhongshan Ophthalmic Center,Sun Yat-sen University, Guangzhou 510060, China |
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| Abstract: | Purpose: To evaluate short-term effects of single photodynamic therapy (PDT) for agerelated macular degeneration (AMD) accompanied with choroidal neovascularization (CNV). Methods : We analyzed retrospectively the effects of single PDT tor 20 patients (20 eyes) with CNV caused by AMD. Corrected visual acuity, fluorescein angiography (FA) and optic coherence tomography (OCT) were examined before and after PDT. All patients were followed up at least 3 months. Results: At the end of 3-month follow-up, 5 eyes had vision progress, 15 eyes had vision stable and no eye had vision deterioration. Fluorescein angiography one week post PDT showed cessation of fluorescein leakage in 8 eyes with predominant classic CNV, and reduction of fluorescein leakage in 12 eyes with minimal classic CNV or occult CNV without classic component. At the 3-month following PDT fluorescein angiography showed fluorescein leakage reappeared in 4 of 8 eyes with predominant classic CNV. Among 12 eyes with minimal classic CNV or occult CNV without classic component, 9 eyes showed decreased or unchanged fluorescein leakage, 3 eyes had a progression of fluorescein leakage. Optic coherence tomography showed obvious recovery of serous sensory retinal detachment after PDT.C onclusion : PDT may occlude or inhibit CNV caused by AMD in short term. No obvious side effects were noticed. Eye Science 2004;20:158-162. |
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| Keywords: | age-related macular degeneration photodynamic therapy choroidal neovas-cularization |
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