| 护肝降酶口服液对四氯化碳所致小鼠慢性肝损伤的保护作用 |
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| 引用本文： | 张宏愿,阎莉.护肝降酶口服液对四氯化碳所致小鼠慢性肝损伤的保护作用[J].抗感染药学,2011,8(2):98-99. |
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| 作者姓名： | 张宏愿 阎莉 |
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| 作者单位： | 1. 南宁市第四人民医院,南宁,530012;广西中医学院,南宁,530001
2. 广西中医学院,南宁,530001 |
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| 基金项目： | 广西自然科学基金自筹项目 |
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| 摘 要： | 目的:观察护肝降酶口服液(Hugan Jiangmei oral medicinal liquid,HGJM)对四氯化碳(CCl4)所致小鼠慢性肝损伤的保护作用。方法:以CCl4诱发小鼠慢性肝纤维化模型,采用灌胃法给予HGJM,测定小鼠血清丙氨酸氨基转移酶(ALT)、天门冬酸氨基转移酶(AST)及肝组织病理改变。结果:HGJM在给药8周后,显著降低血清ALT和AST水平,减轻了肝脏的病理损伤。结论:HGJM对CCl4致小鼠的慢性肝损伤有一定的肝保护作用。
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| 关 键 词： | 四氯化碳 护肝降酶 肝损伤 |
Protective Effect of Hugan Jiangmei Oral Medicinal Liquid on Chronic Liver Injury Induced by Carbon Tetrachloride in Mice |
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| ZHANG Hong-yuan,YAN Li.Protective Effect of Hugan Jiangmei Oral Medicinal Liquid on Chronic Liver Injury Induced by Carbon Tetrachloride in Mice[J].Anti-infection Pharmacy,2011,8(2):98-99. |
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| Authors: | ZHANG Hong-yuan YAN Li |
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| Institution: | 1Νο.4 peoples Hospital of Nanning,Nanning Guangxi 530023;2Guangxi College of TCM,Nanning Guangxi 530001 |
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| Abstract: | Objective:To investigate the effect of Hugan Jiangmei(HGJM) oral medicinal liquid on chronic liver injury induced by carbon tetrachloride(CCl4) in mice.Methods:The levels of aminotransferase(ALT and AST) in serum and liver tissue damage were determined for evaluating the effect of HGJM on CCl4 induced chronic hepatic fibrosis in mice.Results:Oral administration of HGJM decreased ALT,AST level in serum and ameliorated the liver tissue damage induced by CCl4.Conclusion:HGJM had protective effect on mouse chro... |
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| Keywords: | carbon tetrachloride(CCl4) Hugan Jiangmei chronic hepatic injury |
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