| HPLC 法测定盐酸特拉唑嗪胶囊的含量和有关物质 |
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| 引用本文： | 刘剑.HPLC 法测定盐酸特拉唑嗪胶囊的含量和有关物质[J].北方药学,2011,8(7):1-3. |
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| 作者姓名： | 刘剑 |
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| 作者单位： | 内蒙古红十字会包头朝聚眼科医院药械科,包头,014060 |
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| 摘 要： | 目的:建立了HPLC 法测定盐酸特拉唑嗪胶囊的含量及有关物质.方法:色谱柱为Thermo C18柱(250×4.6mm,5μm),流动相:乙腈-三乙胺高氯酸溶液(取三乙胺2ml,置1000ml水中,用高氯酸调节pH2.0)(20:80),检测波长246nm,流速:1.0mL·min-1,柱温:40℃.结果:盐酸特拉唑嗪...
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| 关 键 词： | 高效液相色谱法 盐酸特拉唑嗪胶囊 含量 有关物质 |
HPLC Determination Assay and its related substances of Terazosin Hydrochloride Capsules |
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| Liu Jian.HPLC Determination Assay and its related substances of Terazosin Hydrochloride Capsules[J].BEIFANG YAOXUE,2011,8(7):1-3. |
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| Authors: | Liu Jian |
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| Institution: | Liu Jian(Baotou Chaoju Ophthalmic Hospital Of Inner Mongolia Red Cross,Baotou 014060,China) |
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| Abstract: | Objective：To establish an HPLC method for determination of assay and its related substances of terazosin hydrochloride Capsule.Method：A Thermo C18（250×4.6mm,5μm）column was adopted with a mobile phase of a mixture of triethylamine perchloric acid solution（add 2 ml of triethyiamine to a 1000 ml of water,adjusted pH value to 2.0 with perchloric acid）-acetonitrile（20：80）at a flow rate of 1.0 mL·min-1 and UV detector wavelength at 246 nm,Column tempreture was 40℃.Results：The average recovery of terazosin hydrochloride Capsule（n=9）was 100.4% with RSD=0.3%,The liner ranges of terazosin hydrochloride was 2～34μg·mL-1（r=0.9999）.Conclusion：This method is simple,accurate,sensitive,it can be used for the control of quality of terazosin hydrochloride Capsules. |
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| Keywords: | HPLC Terazosin hydrochloride Capsules Assay Related substances |
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