| 他克莫司滴眼剂的制备及质量评价 |
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| 引用本文： | 张静,吴谧,张晓楠. 他克莫司滴眼剂的制备及质量评价[J]. 齐鲁药事, 2009, 28(5): 295-297 |
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| 作者姓名： | 张静 吴谧 张晓楠 |
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| 作者单位： | 华北制药集团新药研究开发有限责任公司,河北,石家庄,050015 |
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| 摘 要： | 采用固体分散法结合冷冻干燥工艺制备他克莫司滴眼剂,并进行稳定性和兔眼刺激性考察,结果表明,该制剂2～8℃贮存2年稳定性良好,无刺激性,是理想的临床用药.
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| 关 键 词： | 他克莫司 滴眼剂 稳定性 刺激性 |
Preparation and quality evaluation of Tacrolimus Eye Drops |
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| ZHANG Jing,WU Mi,ZHANG Xiao-nan. Preparation and quality evaluation of Tacrolimus Eye Drops[J]. qilu pharmaceutical affairs, 2009, 28(5): 295-297 |
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| Authors: | ZHANG Jing WU Mi ZHANG Xiao-nan |
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| Affiliation: | North China Pharmaceutical New Drug R&D Co.;Ltd.;Shijiazhuang 050015 |
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| Abstract: | Taerolimus Eye Drops were prepared by solid dispersion method and followed by lyophilization, the stability and the irritant test on rabbit eyes were investigated. The results showed that Tacrolimus Eye Drops had been stable stored at 2-8℃ for 2 years and had no eye irritation on rabbit eye balls. It was feasible for the clinical application. |
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| Keywords: | Tacrolimus eye drops stability irritation |
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