Visante—OCT、Sirius及A超测量中央角膜厚度的比较

目的比较Visante-OCT、Sirius与A超测量中央角膜厚度（central corneal thickness，CCT）的差异性，评价三种仪器测量结果的一致性。方法分别用Visante-OCT、Sirius和A超测量43例屈光不正志愿者（均为右眼）的CCT，数据行单因素方差分析、简单线性相关及Bland—Altman分析。结果Visante-OCT、Sirius和A超测量的CCT分别为（522．88±33．53）μm、（538．35±35．05）μm和（532．23±34．16）μm；三种仪器测量结果两两之间均有高度相关性；A超与Visante-OCT测量结果无统计学差异（P=0．2（38），测量差值为（9．35±7．39）μm，两者95％的一致性区间为（-3．4～22．1）μm；A超与Sirius测量CCT差异无统计学意义（P=0．409），测量差值为（-6．12±7．39）μm，两者95％的一致性区间为（-18．9～6．7）μm；Visante-OCT与Sirius测量CCT差异具有统计学意义（P=0．038），测量差值为（-15．47±7．39）μm，两者95％的一致性区间为（-30．2～-0．7）μm。结论Visante-OCT与Sirius用于测量CCT，与A超的一致性较好，在临床使用中可替代A超，但需谨慎选择；Visante-OCT与Sirius测量CCT存在一定差异，两者不能替换使用。

Comparison of Central Corneal Thickness Measurements by Visante-OCF, Sirius and A-scan

Objective To evaluate the differences and agreement in central corneal thickness （CCT） measurements by Visante-OCT, Sirius and A-scan. Methods The CCTs of 43 healthy eyes were measured by Visante-OCT, Sirius and A-scan. The differences, correlations and agreements among three measurements were evaluated with one way analysis of variance （ANOVA）, Pearson correlation coefficients and Bland-Altman plots respectively. Results The measured CCTs were （522. 88 ± 33.53）μm, （538. 35 ± 35.05）μm and （532. 23 ± 34. 16） μm respectively by Visante-OCT, Sirius and scan. There existed high pairwise correlations. The difference between A-scan and VisanteOCT was （9. 35 ± 7. 39）μm which was not significant （P = 0. 208）, and the 95% limit of agreement was （ -3.4 - 22. 1 ）μm. The difference between A-scan and Sirius was （ - 6. 12 ± 7. 39）μm which was not significant （P = 0. 409）, and the 95% limit of agreement was （ - 18. 9 - 6. 7）μm. The difference between Visante-OCT and Sirius measurements was （ - 15.47 ± 7. 39）μm which was significant （P = 0. 038）, and the 95 % limit of agreement was（ - 30.2 - - 0. 7）μm. Conclusion Visante-OCT and Sirius have good coincidence with A-scan in measuring CCT and can replace A-scan in clinic, but cautious selection is needed. Visante-OCT and Siriu measurements have difference and can＇t replace each other.