严重烧伤患者血清可溶性白介素-2受体含量变化及高压氧治疗对其影响

目的：本实验通过观察ＨＢＯＴ对烧伤患者血清可溶性白介素２受体（ｓＩＬ－２Ｒ）含量的影响，探讨其防治烧伤感染的意义。方法：选择烧伤总面积大于３０％或Ⅲ度面积大于１０％的烧伤患者４２例，随机分为高压氧治疗组和非高压氧组，８个时相点抽取静脉血，以ＥＬＩＳＡ法测定其血清ｓＩＬ－２Ｒ含量，同时比较两组患者脓毒症发生率。结果：非ＨＢＯＴ组患者伤后各时相点血清ｓＩＬ－２Ｒ含量显著高于正常；与此相反，ＨＢＯＴ组伤后各时相点血清ｓＩＬ－２Ｒ水平接近正常值，与非ＨＢＯＴ组相比，各时相点血清ｓＩＬ－２Ｒ水平显著降低，与此同时，脓毒症发生率也明显低于非ＨＢＯＴ组。结论：ＨＢＯＴ可显著降低烧伤患者血清ｓＩＬ－２Ｒ含量，故对防治烧伤感染可能有益。

The dynamic changes of the level of serum sIL-2R and the effect on it by hyperbaric oxygen therapy in patients with severe burns.

Objective: The purpose of this study was to investigate the significance of hyperbaric oxygen therapy (HBOT) in preventing and treating burn infections by observing its effect on the level of serun sIL-2R in burn patients. Methods: Forty two burn patients (with more than 30% body surface area of third degree more than 10%) were selected and divided into two groups at random: HBOT group and non-HBOT group, forty healthy blood donors were selected as normal control. The venous blood samples were drawn from 42 patients at 1, 3, 5, 7, 14, 21, 28 and 35 days postburn, and the levels of serum sIL-2R were measured by ELISA method. Then the incidences of sepsis of two groups were compared. Results: In non-HBOT group, the level of serum sIL-2R were profoundly increased at all periods postburn and a higher incidence of sepsis was also manifested (compared with HBOT group), in HBOT group, however, the levels of sIL-2R were close to those in normal control and much lower than those in non-HBOT group at all periods postburn and so was the incidence of sepsis. Conclusion: HBOT may significantly reduce the level of serum sIL-2R in burn patients, so it has a positive effect on the prevention and treatment of burn infections.