Analysis of the roles of bluetongue virus outer capsid proteins VP2 and VP5 in determination of virus serotype |
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| Authors: | PPC Mertens S Pedley J Cowley JN Burroughs AH Corteyn MH Jeggo DM Jennings BM Gorman |
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| Institution: | AFRC Institute of Animal Health, Pirbright Laboratory, England, United Kingdom. |
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| Abstract: | Analyses of reassortant and parental strains of BTV serotypes 3 and 10, in serum neutralization tests, confirmed the major role of outer capsid protein VP2 in determination of virus serotype and its involvement in serum neutralization. However, a reassortant BTV strain (R70), containing protein VP5 derived from BTV 3 and VP2 derived from BTV 10, cross-neutralized with both parental virus strains (BTV 3 and BTV 10). It is concluded that VP5 also plays some part in serotype determination of these virus isolates, as analyzed by serum-neutralization, but its role may be less significant than that of VP2. |
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