| 维甲酸诱导肺癌细胞凋亡的研究 |
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| 引用本文： | 赖燕,文忠.维甲酸诱导肺癌细胞凋亡的研究[J].职业与健康,2001,17(3):2-4. |
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| 作者姓名： | 赖燕 文忠 |
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| 作者单位： | 1. 湖南省劳动卫生职业病防治研究所,湖南省,长沙市,410007
2. 湖南医科大学湘雅医院 |
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| 摘 要： | 目的]探讨维甲酸(RA)诱导肺癌细胞的凋亡.方法]采用吖啶橙(AO)荧光染色及透射电镜(TEM)观察RA作用后的肺癌A59细胞株的凋亡改变.结果]RA(10-5M/L)作用6 d后,A59细胞由2×104/L下降为0.9×104个/L,AO荧光染色后RA处理组较对照组有更多的凋亡细胞及凋亡指数,P＜0.05,(TEM)亦观察到在RA处理组中有明显的凋亡改变.结论]RA能够抑制肺癌细胞的增殖并诱导该肿瘤细胞出现凋亡改变.
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| 关 键 词： | 维甲酸 肺癌 细胞凋亡 |
| 文章编号： | 1004-1257(2001)03-0002-03 |
| 修稿时间： | 2000年4月16日 |
Study on apoptosis of lung carcinoma cells induced by retionoic acid |
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| LAI Yan WEN Zhong.Study on apoptosis of lung carcinoma cells induced by retionoic acid[J].Occupation and Health,2001,17(3):2-4. |
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| Authors: | LAI Yan WEN Zhong |
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| Abstract: | Objective ] To study apoptosis of lung carcinoma cells induced by retionoic acid (RA) . Method ] Apoptosis induced by RA in A59 cell lines of lung cancer was detected with acredine organge (AO) fluororent staining and trans ecetron microscope respectively. Result]After 6 days RA and A59 cell lines were mixed with 5 % C02 incubator, cells were reduced from 20 000/L to 9 000/L, and apoptosis cells and indexes in RA groups were higher than those of control group, P < 0.05. Apoptosis cells or bodies in RA groups were also seen with TEM. Conclusion] RA can inhibit the increase and induce the apoptosis of lung carcinoma cells. |
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| Keywords: | Retinoic acid lung cancer apoptosis |
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