| bcl-2和Fas/FasL系统在肝癌细胞凋亡中的作用 |
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| 引用本文： | 彭志海,韩国新,唐华美,于红,胡宏慧. bcl-2和Fas/FasL系统在肝癌细胞凋亡中的作用[J]. 中华实验外科杂志, 2000, 17(1): 38-39 |
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| 作者姓名： | 彭志海 韩国新 唐华美 于红 胡宏慧 |
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| 作者单位： | 1. 200080,上海市第一人民医院普外科
2. 200080,上海市第一人民医院病理科 |
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| 基金项目： | 上海市科学技术发展基金!( 98XD14 0 2 2 ) |
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| 摘 要： | 目的 探讨ｂｃｌ－２和Ｆａｓ／ＦａｓＬ系统在肝癌细胞凋亡过程中的作用。方法 应用免疫组织化学方法检测３６例肝癌和４９例肝硬化组织中ｂｃｌ－２、Ｆａｓ和ＦａｓＬ的表达，用ＴＵＮＥＬ法检测肝中的细胞凋亡。结果 肝癌组织与肝硬化组织比较， 细胞明显减少；肝癌和肝硬化组织中ｂｃｌ－２的表达率分别为１６．６６％和６７．３４％；Ｆａｓ的表达率分别为５２．７７％和７３．４７％；ＦａｓＬ的表达率分别为７２．２２％
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| 关 键 词： | 肝细胞癌 bcl－2基因 Fas／FasL 细胞凋亡 |
| 修稿时间： | 1999-03-16 |
The effect of bcl-2 and Fas/FasL system on hepatic apoptosis in hepatocellular carcinoma |
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| PENG Zhihai ,HAN Guoxin,TANG Huamei,et al.. The effect of bcl-2 and Fas/FasL system on hepatic apoptosis in hepatocellular carcinoma[J]. Chinese Journal of Experimental Surgery, 2000, 17(1): 38-39 |
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| Authors: | PENG Zhihai HAN Guoxin TANG Huamei et al. |
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| Affiliation: | PENG Zhihai *,HAN Guoxin,TANG Huamei,et al. *Department of General Surgery,Shanghai First People's Hospital,Shanghai 200080,China |
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| Abstract: | Objective To investigate the effect of bcl 2 and Fas/fasL system in the apoptotic process of hepatocellular carcinoma (HCC). Methods Expression of bcl 2, Fas and FasL in HCC and liver cirrhosis (LC) tissues were detected by immunohistochemical method. Apoptosis was detected by TUNEL method. Results Compared with LC, apoptotic cells in HCC tissues were significantly reduced. Expression rate of bcl 2, Fas and FasL in HCC tissues was 16.66 %, 52.77 % and 72.22 % respectively, and those in LC tissues was 67.34 %, 73.47 % and 42.86 % respectively.Conclusion bcl 2 may not play an important role in the apoptosis of HCC cells, and the Fas/FasL system might play an important role in regulation of apoptosis. |
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| Keywords: | Apoptosis Hepatocellular carcinoma bcl-2 Fas FasL |
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