| 哺乳动物中天然抗病毒RNAi的研究现状及其应用前景 |
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| 引用本文： | 宋杰.哺乳动物中天然抗病毒RNAi的研究现状及其应用前景[J].国际生物制品学杂志,2014,37(5):238-243. |
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| 作者姓名： | 宋杰 |
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| 作者单位： | 中国医学科学院医学生物学研究所云南省重大传染病疫苗研发重点实验室,昆明,650118 |
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| 基金项目： | 国家自然科学基金面上项目，“重大新药创制”科技重大专项 |
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| 摘 要： | RNA干扰（RNA interference,RNAi）能够特异性沉默与小干扰RNA（small interfering RNA,siRNA）互补的靶mRNA,在果蝇、线虫、植物和哺乳动物中发挥重要的抗病毒免疫功能.此文概述了抗病毒RNAi途径的发现、抗病毒RNAi的免疫机制、病毒编码的RNAi抑制子、天然抗病毒免疫RNAi在哺乳动物中的研究现状以及抗病毒RNAi的应用前景.
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| 关 键 词： | RNA干扰 免疫 先天 哺乳动物 治疗应用 |
Research progress in intrinsic antiviral RNAi in mammalians and its application prospects |
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| Song Jie.Research progress in intrinsic antiviral RNAi in mammalians and its application prospects[J].International Journal of Biologicals,2014,37(5):238-243. |
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| Authors: | Song Jie |
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| Institution: | ( Yunnan Key Laboratory of Vaccine Research ＆ Development on Severe Infectious Disease, Institute of Medical Biology, Chinese Academy of Medicine Science and Peking Union Medical College, Kunming 650118, China) |
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| Abstract: | The RNA interference （RNAi） plays a key role in antiviral immunity in drosophila,nematode,plants and mammalians via silencing genes encoding mRNA complementary to small interfering RNA.This paper reviews the discovery and mechnism of antiviral RNAi,virus-encoded suppressors of RNAi,the research progress in intrinsic antiviral RNAi in mammalians and its application prospects. |
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| Keywords: | RNA interference Immunity innate Mammals Therapeutic uses |
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