Scirrhous carcinoma of the stomach: A clinical and pathological study of 106 surgical cases |
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Authors: | Shoichiro Hirose MD Hideo Honjou Hikohito Nakagawa Keigo Nishimura Yoshitaka Kuroda Masahiko Tsuji Atsuo Miwa Masanobu Kitagawa |
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Institution: | 1. Department of Internal Medicine, Toyama Prefectural Central Hospital, 2-2-78 Nishinagae, Toyama, Japan 2. Department of Surgery, Toyama Prefectural Central Hospital, 930, Toyama, Japan 3. Department of Clinical Pathology, Toyama Prefectural Central Hospital, 930, Toyama, Japan 4. Department of Pathology, Toyama Medical and Pharmaceutical University Faculty of Medicine, 930-01, Japan
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Abstract: | Clinical and pathological characteristics of scirrhous carcinoma of the stomach were studied in 106 cases treated by gastrectomy
between 1973 and 1983. The male to female ratio was 0.58. The percentage of scirrhous carcinomas to all gastric carcinomas
resected in the same period was three times higher in females than males. The age distribution of the patients suggested that
there were two peaks in the forties and sixties in the male, and in the thirties and fifties in the female. The incidence
of scirrhous carcinoma in all types of gastric carcinoma was significantly higher in the twenties, thirties and forties compared
to the lowest incidence in the seventies. In the female group the primary lesion had a tendency to be adjacent to the fundic
gland area and to avoid intestinal metaplasia. In the male the opposite was recognized. Cancer nests with single cells or
only several cells were common in this type of carcinoma. These findings suggest that there might be two biologically different
scirrhous carcinomas both in the male and the female, the appearance of single carcinoma cells might be favored by female
sex hormones and young ages, and not only the original gastric mucosa but also mucosa with intestinal metaplasia could be
precursors of single carcinoma cells. |
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Keywords: | clinical spectrum pathology scirrhous carcinoma stomach |
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