| 聚乙烯醇-胶原凝胶的研制及其作为组织替代材料的探讨 |
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| 引用本文： | 叶春婷,邹海燕,陈鸿辉,彭燕豪. 聚乙烯醇-胶原凝胶的研制及其作为组织替代材料的探讨[J]. 药物生物技术, 2006, 13(5): 370-372,383 |
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| 作者姓名： | 叶春婷 邹海燕 陈鸿辉 彭燕豪 |
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| 作者单位： | 暨南大学医学院附属广州市红十字会医院,广东,广州,510220 |
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| 摘 要： | 研制一种新型的聚乙烯醇-胶原复合材料。并探讨其作为组织替代材料的可行性。聚乙烯醇（PVA）与Ⅰ型胶原以一定比例混合，真空冷冻干燥成为凝胶状，并对其进行生物安全性评价试验：包括细胞毒性试验与体内埋植试验。结果现示：3T3绌胞任PVA-胶原材料中以含10％新生牛血清的DMEM培养液培养，细胞能三维生长、形态正常；材料体内埋植4周后异物反应消失，材料与周围组织互相融合。因此，PVA-胶原材料无毒副作用，具有良好的细胞相容性与组织相容性，可安全地应用于体内移植。
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| 关 键 词： | 胶原 聚乙烯醇(PVA) 生物材料 |
| 文章编号： | 1005-8915（2006）05-0370-04 |
| 收稿时间： | 2005-09-12 |
| 修稿时间： | 2005-09-122005-12-11 |
The Preparation of Polyvinyl Alcohol-Collagen Gel and Evaluation as Tissue Substitute Materials |
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| YE Chun-ting,ZHOU Hai-yan,CHEN Hong-hui,PENG Yan-hao. The Preparation of Polyvinyl Alcohol-Collagen Gel and Evaluation as Tissue Substitute Materials[J]. Pharmaceutical Biotechnology, 2006, 13(5): 370-372,383 |
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| Authors: | YE Chun-ting ZHOU Hai-yan CHEN Hong-hui PENG Yan-hao |
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| Affiliation: | Guangzhou Red Cross Hospital, The Affiliate of the Medical school of Jinan University,Guangzhou, 510220 |
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| Abstract: | In order to prepare a new compound polyvinyl alcohol(PVA)-collagen for using as tissue substitute material,PVA and collagen were put together and freeze-dried by vacuum to make a gel.Then the biological security tests were done,including the cell toxicity test as well as the test of implanting in rabbit's body.The results indicated that the 3T3 cells could proliferate and grew well in the PVA-collagen porous material.After 4 weeks of implanting,the material got along with the surrounding tissue harmoniously,and the exotic reaction disappeared. The PVA-collagen had good biocompatibility.It was supposed that it can be an ideal biomaterial for tissue substitute. |
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| Keywords: | Polyvinyl alcohol Collagen Biomaterial |
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