| 药物浓度-时间曲线双峰现象研究进展 |
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| 引用本文： | 陈曦,马越鸣,钟杰. 药物浓度-时间曲线双峰现象研究进展[J]. 中国新药与临床杂志, 2012, 0(8): 432-437 |
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| 作者姓名： | 陈曦 马越鸣 钟杰 |
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| 作者单位： | 上海中医药大学中药学院 |
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| 基金项目： | 上海高校创新团队建设项目(2009) |
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| 摘 要： | 很多临床使用药物的浓度-时间(C-T)曲线呈现双峰现象。作为一种特殊的曲线形式,双峰现象增大了C-T曲线的拟合难度,影响了药动学参数的估算,给药动学研究提出了新的问题。本文对双峰现象的形成原因及影响因素、模型构建及拟合的研究现状进行综述。
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| 关 键 词： | 双峰现象 模型 药动学 拟合 |
Research progress in double peak phenomenon of concentration-time curve |
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| CHEN Xi,MA Yue-ming,ZHONG Jie. Research progress in double peak phenomenon of concentration-time curve[J]. Chinese Journal of New Drugs and Clinical Remedies, 2012, 0(8): 432-437 |
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| Authors: | CHEN Xi MA Yue-ming ZHONG Jie |
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| Affiliation: | (College of Pharmacy,Shanghai University of Traditional Chinese Medicine,SHANGHAI 201203,China) |
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| Abstract: | The concentration-time(C-T) curve of many clinical drugs appears a second peak.As a special C-T profile,the second peak increases the difficulty of modeling and simulating of the C-T curve,then impacts the estimation of pharmacokinetic parameters and raises new questions to pharmacokinetic study.This paper reviewed the causes and impact factors,modeling and curve fitting of double peak type C-T curve. |
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| Keywords: | double peak phenomenon modeling pharmacokinetics simulation |
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