| 磷酸哌喹有关物质的检测研究 |
| |
| 引用本文： | 张小松,江生,毛庆.磷酸哌喹有关物质的检测研究[J].中国药事,2009,23(7):690-691. |
| |
| 作者姓名： | 张小松 江生 毛庆 |
| |
| 作者单位： | 重庆市药品检验所,重庆,401121 |
| |
| 摘 要： | 目的建立高效液相色谱法测定磷酸哌喹中的有关物质,考察磷酸哌喹对光的稳定性。方法采用Agilent C18柱,以0.04mol.L-1磷酸二氢钾-乙腈-三乙胺（90∶10∶0.2,用磷酸调节pH至2.5）为流动相,流速：0.5mL.min-1,检测波长：230nm,柱温：25℃。结果磷酸哌喹有关物质含量为0.21%~0.39%,强光照射10d后有明显增加。结论本法准确可靠,简便快捷,适用于磷酸哌喹的质量控制。
|
| 关 键 词： | 磷酸哌喹 有关物质 高效液相色谱法 |
Determination of the Related Substances in Piperaquine Phosphate by HPLC |
| |
| Zhang Xiaosong,Jang Sheng,Mao Qing.Determination of the Related Substances in Piperaquine Phosphate by HPLC[J].Chinese Pharmaceutical Affairs,2009,23(7):690-691. |
| |
| Authors: | Zhang Xiaosong Jang Sheng Mao Qing |
| |
| Institution: | (Chongqing Institute for Drug Control, Chongqing 401121) |
| |
| Abstract: | Objective To observe the irradiation stability of Piperaquine Phosphate and establish a HPLC method for determination of the related substances in Piperaquine Phosphate. Methods The liquid chromatography was carried out on an Agilent C18 column with a mobile phase of 0.04 mol· L^-1 potassium dihydrogen phosphate-acetonitrile-triethylamine （90 ： 10 ： 0.2, adjusted to pH 2.5 with phosphoric acid）. The flow rate was 0.5mL· min^-1. The detection wavelength was 230nm and the column temperature was 25℃. Results The related substances of Piperaquine Phosphate was in the range of 0.21%-0.39%, and it was obviously increased after exposing to the light for 10 days. Conclusions The method is accurate, convenient, rapid, reliable and suitable for the quality control of Piperaquine Phosphate. |
| |
| Keywords: | piperaquine phosphate related substances HPLC |
| 本文献已被 维普 万方数据 等数据库收录！ |
|
